Structure of PDB 7z6z Chain B

Receptor sequence

>7z6zB (length=604) Species: 9606 (Homo sapiens)

LDPGLQPGQFSADEAGAQLFAQSYQSSAEQVLFQSVAASWAHDTNITAEN
ARRQEEAALLSQEFAEAWGQKAKELYEPIWQQFTDPQLRRIIGAVRTLGS
ANLPLAKRQQYNALLSQMSRIYSTAKVCLTCWSLDPDLTNILASSRSYAM
LLFAWEGWHNAAGIPLKPLYEDFTALSNEAYKQDGFTDTGAYWRSWYNSP
TFEDDLEHLYQQLEPLYLNLHAFVRRALHRRYGDRYINLRGPIPAHLLGD
MWAQSWENIYDMVVPFPDKPNLDVTSTMLQQGWQATHMFRVAEEFFTSLE
LSPMPPEFWEGSMLEKPADGREVVCHASAWDFYNRKDFRIKQCTRVTMDQ
LSTVHHEMGHIQYYLQYKDLPVSLRRGANPGFHEAIGDVLALSVSTPEHL
HKIGLLDRVTNDTESDINYLLKMALEKIAFLPFGYLVDQWRWGVFSGRTP
PSRYNFDWWYLRTKYQGICPPVTRNETHFDAGAKFHVPNVTPYIRYFVSF
VLQFQFHEALCKEAGYEGPLHQCDIYRSTKAGAKLRKVLRAGSSRPWQEV
LKDMVGLDALDAQPLLKYFQLVTQWLQEQNQQNGEVLGWPEYQWHPPLPD
NYPE

3D structure

• PDB: 7z6z Structural basis for the inhibition of human angiotensin-1 converting enzyme by fosinoprilat.
• Chain: B
• Resolution: 1.75 Å

Enzymatic activity

• Enzyme Commision number: 3.4.15.1: peptidyl-dipeptidase A.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FUC	B	N416 T418 D421	N411 T413 D416
BS02	KS8	B	Q259 H331 A332 S333 W335 H361 E362 H365 K489 H491 T496 Y498 Y501	Q254 H326 A327 S328 W330 H356 E357 H360 K484 H486 T491 Y493 Y496
BS03	ZN	B	H361 H365 E389	H356 H360 E384
BS04	CA	B	E262 N263 D354	E257 N258 D349

Gene Ontology

Molecular Function

• GO:0008237 metallopeptidase activity
• GO:0008241 peptidyl-dipeptidase activity

Biological Process

• GO:0006508 proteolysis

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:7z6z, PDBe:7z6z, PDBj:7z6z
• PDBsum: 7z6z
• PubMed: 35653492
• UniProt: P12821|ACE_HUMAN Angiotensin-converting enzyme (Gene Name=ACE)