Structure of PDB 7z2z Chain B

Receptor sequence
>7z2zB (length=1104) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
DEINTAQDKWHLLPAFLKVKGLVKQHLDSFNYFVDTDLKKIIKANQLILS
DVDPEFYLKYVDIRVGKKSSSSTKDYLTPPHECRLRDMTYSAPIYVDIEY
TRGRNIIMHKDVEIGRMPIMLRSNKCILYDADESKMAKLNECPLDPGGYF
IVNGTEKVILVQEQLSKNRIIVEADEKKGIVQASVTSSTHERKSKTYVIT
KNGKIYLKHNSIAEEIPIAIVLKACGILSDLEIMQLVCGNDSSYQDIFAV
NLEESSKLDIYTQQQALEYIGAKVKTMRRQKLTILQEGIEAIATTVIAHL
TVEALDFREKALYIAMMTRRVVMAMYNPKMIDDRDYVGNKRLELAGQLIS
LLFEDLFKKFNNDFKLSIDKVLKKPNRAMEYDALLSINVHSNNITSGLNR
AISTGNWSLKRFKMERAGVTHVLSRLSYISALGMMTRISSQFEKSRKVSG
PRALQPSQFGMLCTADTPEGEACGLVKNLALMTHITTDDEEEPIKKLCYV
LGVEDITLIDSASLHLNYGVYLNGTLIGSIRFPTKFVTQFRHLRRTGKVS
EFISIYSNSHQMAVHIATDGGRICRPLIIVSDGQSRVKDIHLRKLLDGEL
DFDDFLKLGLVEYLDVNEENDSYIALYEKDIVPSMTHLEIEPFTILGAVA
GLIPYPHHNQSPRNTYQCAMGKQAIGAIAYNQFKRIDTLLYLMTYPQQPM
VKTKTIELIDYDKLPAGQNATVAVMSYSGYDIEDALVLNKSSIDRGFGRC
ETRRKTTTVLKRYANHTQDIIGGMRVDENGDPIWQHQSLGPDGLGEVGMK
VQSGQIYINKSVPTNSAQTQYREAPVIYRGPEPSHIDQVMMSVSDNDQAL
IKVLLRQNRRPELGDKFSSRHGQKGVCGIIVKQEDMPFNDQGIVPDIIMN
PHGFPSRMTVGKMIELISGKAGVLNGTLEYGTCFGGSKLEDMSKILVDQG
FNYSGKDMLYSGITGECLQAYIFFGPIYYQKLKHMVLDKMHARARGPRAV
LTRQPTEGRSRDGGLRLGEMERDCVIAYGASQLLLERLMISSDAFEVDVC
DKCGLMGYSGWCTTCKSAENIIKMTIPYAAKLLFQELLSMNIAPRLRLED
IFQQ
3D structure
PDB7z2z Structural basis of Ty1 integrase tethering to RNA polymerase III for targeted retrotransposon integration.
ChainB
Resolution3.07 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna B Q708 K919 K1028 H1029 Q673 K874 K983 H984
BS02 dna B E506 H1036 R1054 L1060 M1065 E471 H991 R1009 L1015 M1020
BS03 peptide B G1041 P1042 R1043 A1044 V1045 G996 P997 R998 A999 V1000
BS04 ZN B C1095 C1098 C1050 C1053
Gene Ontology
Molecular Function
GO:0001056 RNA polymerase III activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006383 transcription by RNA polymerase III
GO:0006384 transcription initiation at RNA polymerase III promoter
GO:0006386 termination of RNA polymerase III transcription
GO:0042797 tRNA transcription by RNA polymerase III
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005666 RNA polymerase III complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7z2z, PDBe:7z2z, PDBj:7z2z
PDBsum7z2z
PubMed36977686
UniProtP22276|RPC2_YEAST DNA-directed RNA polymerase III subunit RPC2 (Gene Name=RET1)

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