Structure of PDB 7ytw Chain B

Receptor sequence
>7ytwB (length=507) Species: 10090 (Mus musculus) [Search protein sequence]
DMLYKIEDVPPWYLCILLGFQHYLTCFSGTIAVPFLLAEALCVGRDQHMV
SQLIGTIFTCVGITTLIQTTVGIRLPLFQASAFAFLVPAKSILALERWKC
PSEEEIYGNWSMPLNTSHIWHPRIREVQGAIMVSSMVEVVIGLMGLPGAL
LSYIGPLTVTPTVSLIGLSVFQAAGDRAGSHWGISACSILLIVLFSQYLR
NLTIFKMFPIVLAIMTVWLLCYVLTLTDVLPADPTVYGFQARTDARGDIM
AISPWIRIPYPCQWGLPTVTVAAVLGMFSATLAGIIESIGDYYACARLAG
APPPPVHAINRGIFTEGICCIIAGLLGTGNGSTSSSPNIGVLGITKVGSR
RVVQYGAGIMLILGAIGKFTALFASLPDPILGGMFCTLFGMITAVGLSNL
QFVDMNSSRNLFVLGFSMFFGLTLPNYLDSNPGAINTGIPEVDQILTVLL
TTEMFVGGCLAFILDNTVPGSPEERGLIQWSYDFPFGMGMVKRTTFFRYI
PICPVFR
3D structure
PDB7ytw Structural basis of vitamin C recognition and transport by mammalian SVCT1 transporter.
ChainB
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NA B E341 D345 S388 S389 S390 E287 D291 S334 S335 S336
BS02 NA B I202 E341 I166 E287
BS03 ASC B T66 A116 S117 A118 F119 E341 T387 S389 T30 A80 S81 A82 F83 E287 T333 S335
Gene Ontology
Molecular Function
GO:0008520 L-ascorbate:sodium symporter activity
GO:0015081 sodium ion transmembrane transporter activity
GO:0015143 urate transmembrane transporter activity
GO:0015229 L-ascorbic acid transmembrane transporter activity
GO:0015293 symporter activity
GO:0022857 transmembrane transporter activity
GO:0033300 dehydroascorbic acid transmembrane transporter activity
Biological Process
GO:0006814 sodium ion transport
GO:0007420 brain development
GO:0009636 response to toxic substance
GO:0015747 urate transport
GO:0015882 L-ascorbic acid transmembrane transport
GO:0030324 lung development
GO:0035725 sodium ion transmembrane transport
GO:0055085 transmembrane transport
GO:0070837 dehydroascorbic acid transport
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009925 basal plasma membrane
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0043229 intracellular organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ytw, PDBe:7ytw, PDBj:7ytw
PDBsum7ytw
PubMed36914666
UniProtQ9Z2J0|S23A1_MOUSE Solute carrier family 23 member 1 (Gene Name=Slc23a1)

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