Structure of PDB 7ytv Chain B

Receptor sequence

>7ytvB (length=321) Species: 746128 (Aspergillus fumigatus)

MVHTKVVIIGSGPAAHTAAIYLSRAELKPVLYEGMANAAGGQLTTTTDIE
NFPGFPDGIGGAELMENMRKQSIRFGTEVITETISRVDLSSKPFKLWTEW
NDGPDKEPACTADAVIIATGANARRLNLPGEETYWQNGISACAVCDGAVP
IFRNKPLYVIGGDSAAEEAMFLAKYGSSVTVLVRRDKLRASKAMAKRLLA
HPKVTVRFNTVATEVLGEKKPNGLMTHLRIKNTVTGEEEIVDANGLFYAV
GHDPATALVKGQIDLDEDGYIITKPGTSYTSREGVFACGVQDKRYRQAIT
SAGSGCIAALEAEKFIAEAES

3D structure

• PDB: 7ytv In vitro antifungal and antibiofilm activities of auranofin against itraconazole-resistant Aspergillus fumigatus.
• Chain: B
• Resolution: 3.866 Å

Enzymatic activity

• Enzyme Commision number: 1.8.1.9: thioredoxin-disulfide reductase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAP	B	G165 G166 S168 R188 R193 V254	G161 G162 S164 R184 R189 V250
BS02	FAD	B	I9 G10 S11 G12 P13 A14 Y32 A41 Q45 L46 T49 N54 T86 I87 T122 G123 W138 A144 C148 L262 R301 Q302 A303 S306	I9 G10 S11 G12 P13 A14 Y32 A38 Q42 L43 T46 N51 T83 I84 T119 G120 W135 A141 C145 L258 R296 Q297 A298 S301

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0004791 thioredoxin-disulfide reductase (NADPH) activity
• GO:0016491 oxidoreductase activity

Biological Process

• GO:0019430 removal of superoxide radicals
• GO:0045454 cell redox homeostasis

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:7ytv, PDBe:7ytv, PDBj:7ytv
• PDBsum: 7ytv
• PubMed: 37037064
• UniProt: A0A229Y1X4