Structure of PDB 7ymk Chain B

Receptor sequence

>7ymkB (length=220) Species: 9606 (Homo sapiens) [Search protein sequence]

GSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRE
LVHMINWAKRVPGFVDLTLHDQVHLLESAWLEILMIGLVWRSMEHPGKLL
FAPNLLLDRNQGKSVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIIL
LNSGVYTFSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLA
QLLLILSHIRHMSNKGMEHL

3D structure

PDB

7ymk Discovery of novel covalent selective estrogen receptor degraders against endocrine-resistant breast cancer

Chain

Resolution

2.25 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	I358 K362 L372 H373	I55 K59 L69 H70
BS02	IX0	B	L346 T347 A350 E353 L384 L387 L391 F404 I424 G521 L525	L43 T44 A47 E50 L81 L84 L88 F101 I121 G216 L220

External links

PDB	RCSB:7ymk, PDBe:7ymk, PDBj:7ymk
PDBsum	7ymk
PubMed	38045063
UniProt	P03372\|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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