Structure of PDB 7yly Chain B

Receptor sequence

>7ylyB (length=518) Species: 4932 (Saccharomyces cerevisiae)

VQIFGDQVTEERAENARLSAFVGAIAVGDLVKSTLGPKGMDKLLQSASSN
TCMVTNDGATILKSIPLDNPAAKVLVNISKVQDDEVGDGTTSVTVLSAEL
LREAEKLIDQSKIHPQTIIEGYRLASAAALDALTKAAVDNSHDKTMFRED
LIHIAKTTLSSKILSQDKDHFAELATNAILRLKGSTNLEHIQIIKILGGK
LSDSFLDEGFILAKKFGNNQPKRIENAKILIANTTLDTDKVKIFGTKFKV
DSTAKLAQLEKAEREKMKNKIAKISKFGINTFINRQLIYDYPEQLFTDLG
INSIEHADFEGVERLALVTGGEVVSTFDEPSKCKLGECDVIEEIMLGEQP
FLKFSGCKAGEACTIVLRGATDQTLDEAERSLHDALSVLSQTTKETRTVL
GGGCAEMVMSKAVDTEAQNIDGKKSLAVEAFARALRQLPTILADNAGFDS
SELVSKLRSSIYNGISTSGLDLNNGTIADMRQLGIVESYKLKRAVVSSAS
EAAEVLLRVDNIIRARPR

3D structure

• PDB: 7yly Structural basis of plp2-mediated cytoskeletal protein folding by TRiC/CCT.
• Chain: B
• Resolution: 3.05 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ADP	B	P39 D90 G91 T93 S94 S162 S163 G404 I487 E489	P37 D88 G89 T91 S92 S160 S161 G402 I485 E487
BS02	AF3	B	D59 D90 T92 K164 D386	D57 D88 T90 K162 D384

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity
• GO:0051082 unfolded protein binding
• GO:0140662 ATP-dependent protein folding chaperone

Biological Process

• GO:0006457 protein folding
• GO:0051086 chaperone mediated protein folding independent of cofactor

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005832 chaperonin-containing T-complex

External links

• PDB: RCSB:7yly, PDBe:7yly, PDBj:7yly
• PDBsum: 7yly
• PubMed: 36921056
• UniProt: P39076|TCPB_YEAST T-complex protein 1 subunit beta (Gene Name=CCT2)