Structure of PDB 7yfh Chain B

Receptor sequence
>7yfhB (length=652) Species: 10116 (Rattus norvegicus) [Search protein sequence]
AVTVAVVFGSSGPLQTQARTRLTSQNFLDLPLEIQPLTVGVNNTNPSSIL
TQICGLLGAARVHGIVFEDNVDTEAVAQLLDFVSSQTHVPILSISGGSAV
VLTPKEPGSAFLQLGVSLEQQLQVLFKVLEEYDWSAFAVITSLHPGHALF
LEGVRAVADASYLSWRLLDVLTLELGPGGPRARTQRLLRQVDAPVLVAYC
SREEAEVLFAEAAQAGLVGPGHVWLVPNLALGSTDAPPAAFPVGLISVVT
ESWRLSLRQKVRDGVAILALGAHSYRRQYGTLPAPAGDCRSHPGPVSPAR
EAFYRHLLNVTWEGRDFSFSPGGYLVRPTMVVIALNRHRLWEMVGRWDHG
VLYMKYPVWPRYSTSLQPVVDSRHLTVATLEERPFVIVESPDPGTGGCVP
NTVPCRRQSNHTFSSGDLTPYTKLCCKGFCIDILKKLAKVVKFSYDLYLV
TNGKHGKRVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIIDFSVPFVE
TGISVMVSRSDTVSGLSDKKFQRPQDQYPPFRFGTVPNGSTERNIRSNYR
DMHTHMVKFNQRSVEDALTSLKMGKLDAFIYDAAVLNYMAGKDEGCKLVT
IGSGKVFATTGYGIAMQKDSHWKRAIDLALLQLLGDGETQKLETVWLSGI
CQ
3D structure
PDB7yfh Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits.
ChainB
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLU B H483 S509 T511 R516 G686 S687 T688 Y728 H455 S481 T483 R488 G539 S540 T541 Y581
BS02 IWB B W162 S163 R194 D220 A221 P222 A466 K470 W134 S135 R166 D192 A193 P194 A438 K442
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0015276 ligand-gated monoatomic ion channel activity
GO:0038023 signaling receptor activity
Biological Process
GO:0006811 monoatomic ion transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7yfh, PDBe:7yfh, PDBj:7yfh
PDBsum7yfh
PubMed36959261
UniProtQ00961|NMDE3_RAT Glutamate receptor ionotropic, NMDA 2C (Gene Name=Grin2c)

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