Structure of PDB 7yfe Chain B

Receptor sequence
>7yfeB (length=1069) Species: 538123 (Mammalian orthoreovirus 3) [Search protein sequence]
PPTASSGHGYQCHVCSAVLFSPLDLDAHVASHGLNRKTAQLLHADTPRLV
TWDAGLCTSFKIVPIVPAQVPQDVLAYTFFTSSYAIQSPFPEAAVSRIVV
HTRWASNVDFDRDSSVIMAPPTENNIHLFKQLLNTETLSVRGANPLMFRA
NVLHMLLEFVLDNLYLNRHTGFSQDHTPFTEGANLRSLPGPDAEKWYSIM
YPTRMGTPNVSKICNFVASCVRNRVGRFDRAQMMNGAMSEWVDVFETSDA
LTVSIRGRWMARLARMNINPTEIEWALTECAQGYVTVTSPYAPSVNRLMP
YRISNAERQISQIIRVMNIGNNATVIQPVLQDISVLLQRISPLQIDPTII
SNTMSTVSESTTQTLSPASSILGKLRPSNSDFSSFRVALAGWLYNGVVTT
VIDDSSYPKDGGSVTSLENLWDFFILALALPLTTDPCAPVKAFMTLANMM
VGFETIPMDNQIYTQSRRASAFSTPHTWPRCFMNIQLISPIDAPILRQWA
EIIHRYWPNPSQIRYGTPNVFGSANLFTPPEVLLLPIDHQPANVTTPTLD
FTNELTNWRARVCELMKNLVDNQRYQPGWTQSLVSSMRGTLGKLKLIKSM
TPMYLQQLAPVELAVIAPMLPFPPFQVPYVRLDRDRVPTMVGVTRQSRDT
ITQPALSLSTTNTTVGVPLALDARAITVALLSGKYPPDLVTNVWYADAIY
PMYADTEVFSNLQRDVITCEAVQTLVTLVAQISETQYPVDRYLDWIPSLR
ASAATAATFAEWVNTSMKTAFDLSDMLLEPLLSGDPRMTQLAIQYQQYNG
RTFNVIPEMPGSVIADCVQLTAEVFNHEYNLFGIARGDIIIGRVQSTHLW
SPLAPPPDLVFDRDTPGVHIFGRDCRISFGMNGAAPMIRDETGMMVPFEG
NWIFPLALWQMNTRYFNQQFDAWIKTGELRIRIEMGAYPYMLHYYDPRQY
ANAWNLTSAWLEEITPTSIPSVPFMVPISSDHDISSAPAVQYIISTEYND
RSLFCTNSSSPQTIAGPDKHIPVERYNILTNPDAPPTQIQLPEVVDLYNV
VTRYAYETPPITAVVMGVP
3D structure
PDB7yfe In situ structures of polymerase complex of mammalian reovirus illuminate RdRp activation and transcription regulation.
ChainB
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 ZN B C183 C186 H199 H203 C12 C15 H28 H32
Gene Ontology
Molecular Function
GO:0003724 RNA helicase activity
GO:0004386 helicase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006370 7-methylguanosine mRNA capping
Cellular Component
GO:0019028 viral capsid
GO:0039625 viral inner capsid

View graph for
Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:7yfe, PDBe:7yfe, PDBj:7yfe
PDBsum7yfe
PubMed36469786
UniProtC9E874

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