Structure of PDB 7yf3 Chain B

Receptor sequence
>7yf3B (length=266) Species: 9606 (Homo sapiens) [Search protein sequence]
NHQWYVCNREKLCESLQAVFVQSYLDQGTQIFLNNSIEKSGWAAIQAYHS
AVSSAFSLAMSRTSINGLLGRGSMFVFSPDQFQRLLKINPDWKTHRLLDL
GAGDGEVTKIMSPHFEEIYATELSETMIWQLQKKKYRVLGINEWQNTGFQ
YDVISCLNLLDRCDQPLTLLKDIRSVLEPTRGRVILALVLPFHPYVENVG
GKWEKPSEILEIKGQNWEEQVNSLPEVFRKAGFVIEAFTRLPYLCEGDMY
NDYYVLDDAVFVLKPV
3D structure
PDB7yf3 Molecular basis for METTL9-mediated N1-histidine methylation
ChainB
Resolution3.434 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B S105 G124 M126 N210 D213 R214 Y295 C297 D300 Y302 Y306 L308 S53 G72 M74 N158 D161 R162 Y243 C245 D248 Y250 Y254 L256
BS02 SAH B G153 E174 L175 L209 L211 Y295 G101 E122 L123 L157 L159 Y243
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0106370 protein-L-histidine N-pros-methyltransferase activity
Biological Process
GO:0032259 methylation
Cellular Component
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum

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Biological Process
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Cellular Component
External links
PDB RCSB:7yf3, PDBe:7yf3, PDBj:7yf3
PDBsum7yf3
PubMed37015930
UniProtQ9H1A3|METL9_HUMAN Protein-L-histidine N-pros-methyltransferase (Gene Name=METTL9)

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