Structure of PDB 7ydx Chain B

Receptor sequence
>7ydxB (length=261) Species: 9606 (Homo sapiens) [Search protein sequence]
VIKMKSSDFLEGKVSLAFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMM
NRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGR
IILEIIEGMAYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSK
LNNEGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAIA
EQQLIMAIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEE
KFRPFYLSQLE
3D structure
PDB7ydx Generative deep learning enables the discovery of a potent and selective RIPK1 inhibitor.
ChainB
Resolution2.642 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3CI B I43 V76 M92 M95 L145 I154 A155 D156 L157 L159 I26 V59 M75 M78 L128 I137 A138 D139 L140 L142
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7ydx, PDBe:7ydx, PDBj:7ydx
PDBsum7ydx
PubMed36371441
UniProtQ13546|RIPK1_HUMAN Receptor-interacting serine/threonine-protein kinase 1 (Gene Name=RIPK1)

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