Structure of PDB 7yb7 Chain B

Receptor sequence
>7yb7B (length=138) Species: 9606 (Homo sapiens) [Search protein sequence]
MDNREIVMKYISYKLSQRGYEWDESEVVHQTLRQAGDDFSLRYRRDFAEM
SSQLHLTPGTAYASFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNRE
MSVLVDNIAAWMATYLNDHLHTWIQDNGGWDAFVELYG
3D structure
PDB7yb7 Cyclic peptides discriminate BCL-2 and its clinical mutants from BCL-XL by engaging a single-residue discrepancy
ChainB
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B Y58 D61 F62 E86 L87 D90 N93 G95 R96 A99 L151 Y152 Y43 D46 F47 E71 L72 D75 N78 G80 R81 A84 L136 Y137
BS02 IQ8 B G91 V92 N93 W94 R96 L151 G76 V77 N78 W79 R81 L136
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:7yb7, PDBe:7yb7, PDBj:7yb7
PDBsum7yb7
PubMed38368459
UniProtP10415|BCL2_HUMAN Apoptosis regulator Bcl-2 (Gene Name=BCL2);
Q07817|B2CL1_HUMAN Bcl-2-like protein 1 (Gene Name=BCL2L1)

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