Structure of PDB 7y8g Chain B

Receptor sequence
>7y8gB (length=236) Species: 9606 (Homo sapiens) [Search protein sequence]
GSLALSLTADQMVSALLDAEPPILYSEYDPPFSASMMGLLTNLADRELVH
MINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAP
NLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNS
GVYTFSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLL
LILSHIRHMSNKGMEHLYSMKCPLSDLLLEMLDAHR
3D structure
PDB7y8g Structure-guided identification of novel dual-targeting estrogen receptor alpha degraders with aromatase inhibitory activity for the treatment of endocrine-resistant breast cancer.
ChainB
Resolution2.14 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B I358 K362 L372 Q375 V376 E542 M543 I52 K56 L66 Q69 V70 E230 M231
BS02 IAT B M343 T347 A350 E353 L387 M388 F404 V418 E419 I424 H524 L525 M528 L540 M37 T41 A44 E47 L81 M82 F98 V112 E113 I118 H216 L217 M220 L228
External links
PDB RCSB:7y8g, PDBe:7y8g, PDBj:7y8g
PDBsum7y8g
PubMed37037140
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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