Structure of PDB 7y8f Chain B

Receptor sequence
>7y8fB (length=220) Species: 9606 (Homo sapiens) [Search protein sequence]
AGSLALSLTADQMVSALLDAEPPILYSEYRPFSSMMGLLTNLADRELVHM
INWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPN
LLLDRNQGKCVGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGV
YTFSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLI
LSHIRHMSNKGMEHLYSLLE
3D structure
PDB7y8f Structure-guided identification of novel dual-targeting estrogen receptor alpha degraders with aromatase inhibitory activity for the treatment of endocrine-resistant breast cancer.
ChainB
Resolution2.22 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B I358 K362 L372 H373 V376 E542 I51 K55 L65 H66 V69 E220
BS02 IC7 B M343 L346 A350 E353 L387 M388 F404 V418 G420 M421 I424 G521 H524 L525 L540 M36 L39 A43 E46 L80 M81 F97 V111 G112 M113 I116 G211 H214 L215 L218
External links
PDB RCSB:7y8f, PDBe:7y8f, PDBj:7y8f
PDBsum7y8f
PubMed37037140
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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