Structure of PDB 7y0a Chain B

Receptor sequence
>7y0aB (length=383) Species: 9606 (Homo sapiens) [Search protein sequence]
YQSVELPETHQMLLQTCRDFAEKELFPIAAQVDKEHLFPAAQVKKMGGLG
LLAMDVPEELGGAGLDYLAYAIAMEEISRGCASTGVIMSVNNSLYLGPIL
KFGSKEQKQAWVTPFTSGDKIGCFALSEPGNGSDAGAASTTARAEGDSWV
LNGTKAWITNAWEASAAVVFASTDRALQNKGISAFLVPMPTPGLTLGKKE
DKLGIRGSSTANLIFEDCRIPKDSILGEPGMGFKIAMQTLDMGRIGIASQ
ALGIAQTALDCAVNYAENRMAFGAPLTKLQVIQFKLADMALALESARLLT
WRAAMLKDNKKPFIKEAAMAKLAASEAATAISHQAIQILGGMGYVTEMPA
ERHYRDARITEIYEGTSEIQRLVIAGHLLRSYR
3D structure
PDB7y0a Crystal structure of human short-chain acyl-CoA dehydrogenase
ChainB
Resolution2.317 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.3.8.1: short-chain acyl-CoA dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD B R297 F300 L304 L307 V309 Q365 I366 G368 G369 R269 F272 L276 L279 V281 Q337 I338 G340 G341
BS02 FAD B F152 L154 S155 G160 S161 W185 T187 I387 Y391 T394 E396 I397 L400 F124 L126 S127 G132 S133 W157 T159 I359 Y363 T366 E368 I369 L372
Gene Ontology
Molecular Function
GO:0003995 acyl-CoA dehydrogenase activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
GO:0016937 short-chain fatty acyl-CoA dehydrogenase activity
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0006631 fatty acid metabolic process
GO:0006635 fatty acid beta-oxidation
GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase
GO:0046359 butyrate catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005813 centrosome

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Molecular Function
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Cellular Component
External links
PDB RCSB:7y0a, PDBe:7y0a, PDBj:7y0a
PDBsum7y0a
PubMed
UniProtP16219|ACADS_HUMAN Short-chain specific acyl-CoA dehydrogenase, mitochondrial (Gene Name=ACADS)

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