Structure of PDB 7xzp Chain B

Receptor sequence
>7xzpB (length=559) Species: 1261 (Peptostreptococcus anaerobius) [Search protein sequence]
MMEFKTDIEIAQEANPQDIRDIAKKINLSEDDIELYGKYKAKIDYNVLNR
TKSRAGKLILTTAINPTPAGEGKTTTSIGVADALAKLGKNVIAALREPSM
GPVFGIKGGAAGGGYAQVVPMEDINLHFTGDMHAIGAANNLLAAMLDNHV
YQTNSLNINPKRITWRRCVDMNDRQLRNVVDGLGKKVDGVTREDGFDITV
ASEVMAAFCLSNNISELKENLGNIVVAYNYSGKPVTARDLNAHGAMAAIL
KDALKPNLVQTLEGTPAILHGGPFANIAHGCNSIIATKMGMHMADYVVTE
AGFGADLGAEKFLDIKCRKAGIRPDAVIIVATVRALKYNGGVAKDQLNNE
NLEALEKGLPNLLKHIENITQVYKIPAVVAINRFPLDTDAELALVRSKCE
ELGVKVALSEVWANGGEGGIEVANEVLKLIEEGENNFEYCYEEDMTIKEK
LNAIATKIYGADGVNYTKEANKQIAELEELGFGNLPVCVAKTQYSLSDDQ
TKLGRPTGFTIEVRQANISAGAGFVVVMTGEIMKMPGLPKLPAAERIDVD
ENGKISGLF
3D structure
PDB7xzp Berberine targets FtfL to suppress intestinal bacteria that promote colorectal carcinogenesis
ChainB
Resolution2.56 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.4.3: formate--tetrahydrofolate ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PRO B Y150 V186 Y151 V187
BS02 BER B E70 G71 N381 F383 P384 W411 E71 G72 N382 F384 P385 W412
BS03 BER B Q370 E400 L401 G402 Q371 E401 L402 G403
BS04 PRO B E218 R237 H242 E219 R238 H243
BS05 PRO B R173 R176 M532 R174 R177 M533
BS06 PRO B F436 Y438 F437 Y439
BS07 PRO B M290 I321 R322 D324 M291 I322 R323 D325
Gene Ontology
Molecular Function
GO:0004329 formate-tetrahydrofolate ligase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
Biological Process
GO:0006730 one-carbon metabolic process
GO:0035999 tetrahydrofolate interconversion

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Molecular Function
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Biological Process
External links
PDB RCSB:7xzp, PDBe:7xzp, PDBj:7xzp
PDBsum7xzp
PubMed38049785
UniProtA0A379CIH2

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