Structure of PDB 7xzo Chain B

Receptor sequence
>7xzoB (length=556) Species: 1261 (Peptostreptococcus anaerobius) [Search protein sequence]
FKTDIEIAQEANPQDIRDIAKKINLSEDDIELYGKYKAKIDYNVLNRTKS
RAGKLILTTAINPTPAGEGKTTTSIGVADALAKLGKNVIAALREPSMGPV
FGIKGGAAGGGYAQVVPMEDINLHFTGDMHAIGAANNLLAAMLDNHVYQT
NSLNINPKRITWRRCVDMNDRQLRNVVDGLGKKVDGVTREDGFDITVASE
VMAAFCLSNNISELKENLGNIVVAYNYSGKPVTARDLNAHGAMAAILKDA
LKPNLVQTLEGTPAILHGGPFANIAHGCNSIIATKMGMHMADYVVTEAGF
GADLGAEKFLDIKCRKAGIRPDAVIIVATVRALKYNGGVAKDQLNNENLE
ALEKGLPNLLKHIENITQVYKIPAVVAINRFPLDTDAELALVRSKCEELG
VKVALSEVWANGGEGGIEVANEVLKLIEEGENNFEYCYEEDMTIKEKLNA
IATKIYGADGVNYTKEANKQIAELEELGFGNLPVCVAKTQYSLSDDQTKL
GRPTGFTIEVRQANISAGAGFVVVMTGEIMKMPGLPKLPAAERIDVDENG
KISGLF
3D structure
PDB7xzo Berberine targets FtfL to suppress intestinal bacteria that promote colorectal carcinogenesis
ChainB
Resolution2.31 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.4.3: formate--tetrahydrofolate ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP B G71 K72 T73 T74 G111 F383 W411 G69 K70 T71 T72 G109 F381 W409
BS02 BU3 B I374 P375 I372 P373
BS03 BU3 B R161 Y227 E475 L476 R159 Y225 E473 L474
BS04 BU3 B N219 N222 N217 N220
Gene Ontology
Molecular Function
GO:0004329 formate-tetrahydrofolate ligase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
Biological Process
GO:0006730 one-carbon metabolic process
GO:0035999 tetrahydrofolate interconversion

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Molecular Function
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Biological Process
External links
PDB RCSB:7xzo, PDBe:7xzo, PDBj:7xzo
PDBsum7xzo
PubMed38049785
UniProtA0A379CIH2

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