Structure of PDB 7xur Chain B

Receptor sequence
>7xurB (length=363) Species: 9606 (Homo sapiens) [Search protein sequence]
NFPEYELPELNTRAFHVGAFGELWRGRLRGAGDLSLREPADSDREDAAVA
RDLDCSLEAAAELRAVCGLDKLDPEVIPENTDLVTLGVRKRFLEHREETI
TIDRACRQETFVYEMESHAIGKKPENSADMIEEGELILSVNILYPVIFHK
HKEHKPYQTMLVLGSQKLTQLRDSIRCVSDLQIGGEFSNTPDQISKDLYK
SAFFYFEGTFYNDKRYPECRDLSRTIIEWSESHDRGYGKFQTARMEDFTF
NDLCIKLGFPYLYCHQGDCEHVIVITDIRLVHHDDCLDRTLYPLLIKKHW
LWTRKCFVCKMYTARWVTNNDSFAPEDPCFFCDVCFRMLHYDSEGNKLGE
FLAYPYVDPGTFN
3D structure
PDB7xur Structural basis of human SNAPc recognizing proximal sequence element of snRNA promoter.
ChainB
Resolution3.49 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B H193 K194 H195 W350 H149 K150 H151 W302
BS02 dna B R151 W350 T351 R107 W302 T303
BS03 ZN B C221 H313 H319 C177 H265 H271
BS04 ZN B C354 C357 C383 C306 C309 C335
Gene Ontology
Molecular Function
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000995 RNA polymerase III general transcription initiation factor activity
GO:0001006 RNA polymerase III type 3 promoter sequence-specific DNA binding
GO:0001046 core promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003681 bent DNA binding
GO:0005515 protein binding
Biological Process
GO:0006366 transcription by RNA polymerase II
GO:0006383 transcription by RNA polymerase III
GO:0009301 snRNA transcription
GO:0042795 snRNA transcription by RNA polymerase II
GO:0042796 snRNA transcription by RNA polymerase III
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0016604 nuclear body
GO:0019185 snRNA-activating protein complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:7xur, PDBe:7xur, PDBj:7xur
PDBsum7xur
PubMed36369505
UniProtQ92966|SNPC3_HUMAN snRNA-activating protein complex subunit 3 (Gene Name=SNAPC3)

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