Structure of PDB 7xul Chain B

Receptor sequence
>7xulB (length=690) Species: 9606 (Homo sapiens) [Search protein sequence]
QYIVARPVYSTNAFEENHKKTLDHLKVCCSCSPQKAKRIVLSLFPIASWL
PAYRLKEWLLSDIVSGISTGIVAVLQGLAFALLVDIPPVYGLYASFFPAI
IYLFFGTSRHISVGPFPILSMMVGLAVSGAVSKAVPLLDDERVRVAAAAS
VTVLSGIIQLAFGILRIGFVVIYLSESLISGFTTAAAVHVLVSQLKFIFQ
LTVPSHTDPVSIFKVLYSVFSQIEKTNIADLVTALIVLLVVSIVKEINQR
FKDKLPVPIPIEFIMTVIAAGVSYGCDFKNRFKVAVVGDMNPGFQPPITP
DVETFQNTVGDCFGIAMVAFAVAFSVASVYSLKYDYPLDGNQELIALGLG
NIVCGVFRGFAGSTALSRSAVQESTGGKTQIAGLIGAIIVLIVVLAIGFL
LAPLQKSVLAALALGNLKGMLMQFAEIGRLWRKDKYDCLIWIMTFIFTIV
LGLGLGLAASVAFQLLTIVFRTQFPKCSTLANIGRTNIYKNKKDYYDMYE
PEGVKIFRCPSPIYFANIGFFRRKLIDAVGFSPLRILRKRNKALRKIRKL
QKQGLLQGFICTVDTIKDSDEELDNNQIEVLDQPINTTDLPFHIDWNDDL
PLNIEVPKISLHSLILDFSAVSFLDVSSVRGLKSILQEFIRIKVDVYIVG
TDDDFIEKLNRYEFFDGEVKSSIFFLTIHDAVLHILMKKD
3D structure
PDB7xul Structure of human SLC26A3 in complex with Tenidap
ChainB
Resolution3.16 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Y01 B Q337 V340 Q306 V309
BS02 Y01 B I188 F193 V333 I157 F162 V302
BS03 I2U B V86 L89 Q90 E293 S398 L443 N447 V72 L75 Q76 E262 S367 L412 N416
BS04 Y01 B P240 V481 P209 V450
BS05 Y01 B K245 Y248 K214 Y217
Gene Ontology
Molecular Function
GO:0005452 solute:inorganic anion antiporter activity
GO:0005515 protein binding
GO:0008271 secondary active sulfate transmembrane transporter activity
GO:0015106 bicarbonate transmembrane transporter activity
GO:0015108 chloride transmembrane transporter activity
GO:0015116 sulfate transmembrane transporter activity
GO:0015297 antiporter activity
GO:0019531 oxalate transmembrane transporter activity
GO:0140900 chloride:bicarbonate antiporter activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006820 monoatomic anion transport
GO:0015701 bicarbonate transport
GO:0019532 oxalate transport
GO:0048240 sperm capacitation
GO:0051454 intracellular pH elevation
GO:0055085 transmembrane transport
GO:0060081 membrane hyperpolarization
GO:0071320 cellular response to cAMP
GO:1902358 sulfate transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0031526 brush border membrane
GO:0097225 sperm midpiece

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7xul, PDBe:7xul, PDBj:7xul
PDBsum7xul
PubMed
UniProtP40879|S26A3_HUMAN Chloride anion exchanger (Gene Name=SLC26A3)

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