Structure of PDB 7xuc Chain B

Receptor sequence

>7xucB (length=269) Species: 9606 (Homo sapiens)

RTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDR
NITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEEPPLIFECNQA
CSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGE
LISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNII
PVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQC
GSEKCKHSAEAIALEQSRL

3D structure

• PDB: 7xuc Discovery of Novel Substrate-Competitive Lysine Methyltransferase G9a Inhibitors as Anticancer Agents.
• Chain: B
• Resolution: 1.67 Å

Enzymatic activity

• Enzyme Commision number: 2.1.1.-
  2.1.1.367: [histone H3]-lysine(9) N-methyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	B	C974 C987 C1017 C1021	C58 C71 C97 C101
BS02	ZN	B	C980 C1017 C1023 C1027	C64 C97 C103 C107
BS03	ZN	B	C974 C976 C980 C985	C58 C60 C64 C69
BS04	ZN	B	C1115 C1168 C1170 C1175	C195 C248 C250 C255
BS05	SFG	B	M1048 W1050 S1084 Y1085 R1109 F1110 N1112 H1113 Y1154 F1166 C1168 Q1169	M128 W130 S164 Y165 R189 F190 N192 H193 Y234 F246 C248 Q249
BS06	I6S	B	D1083 L1086 F1087 D1088 F1152 Y1154 F1158 I1161	D163 L166 F167 D168 F232 Y234 F238 I241

Gene Ontology

Molecular Function

• GO:0002039 p53 binding
• GO:0008270 zinc ion binding
• GO:0016279 protein-lysine N-methyltransferase activity
• GO:0042054 histone methyltransferase activity

Cellular Component

• GO:0005634 nucleus

External links

• PDB: RCSB:7xuc, PDBe:7xuc, PDBj:7xuc
• PDBsum: 7xuc
• PubMed: 36882960
• UniProt: Q96KQ7|EHMT2_HUMAN Histone-lysine N-methyltransferase EHMT2 (Gene Name=EHMT2)