Structure of PDB 7xtd Chain B

Receptor sequence
>7xtdB (length=1164) Species: 460519 (Komagataella phaffii) [Search protein sequence]
DDTITTEDCWTVISAFFEEKGLVSQQLDSFDEFMETSIQDLVWEEPRLIL
DQPAQHDNINKRYEIRFGKIYLSRPTMTEADGTTHAMFPQEARLRNLTYS
SPVYLDMEKSMFTSIDGNKVHIGKVPIMLRSKFCSLRTLDEVDLYKMKEC
PYDMGGYFVINGSEKVLIAQERSAANIVQVFKKAAPSPISHVAEIRSALE
KGSRLISTMQIKLYGREDKGTGRTIKATLPYVKQDIPIVIVFRALGVVPD
GEILQHICYDENDWQMLEMLKPCIEEGFVIQDKEVALDFIGRRGSAALGI
RREKRIQYAKDILQKELLPHITQEEGFETRKTFFLGYMVNRLLLCALERK
DQDDRDHFGKKRLDLAGPLLANLFRILFRKLTREIYRYMQRCIETDRDFN
LNLAVKSTTITSGLKYSLATGNWGEQKKAMSSRAGVSQVLNRYTYSSTLS
HLRRTNTPIGRDGKLAKPRQLHNTHWGLVCPAETPEGQACGLVKNLSLLS
GISIGSPSEPIINFLEEWGMEPLEDYDPAQHTKSTRIFVNGVWTGIHRDP
SMLVSTMRDLRRSGAISPEVSIIRDIREREFKIFTDVGRVYRPLFIVEDD
ESKDNKGELRITKEHIRKIQQGYDDDVYGWSSLVTSGVIEYVDGEEEETI
MIAMTPEDLQTNDTAKRIKPEMSTSSHHTFTHCEIHPSMILGVAASIIPF
PDHNQSPRNTYQSAMGKQAMGVFLTNYNVRMDTMANILYYPQKPLAKTQA
MEYLKFRELPAGQNAIVAIACYSGYNQEDSMIMNQSSIDRGLFRSLFFRS
YMDQEKRFGISIVEEFEKPTRATTLRLKHGTYEKLDEDGLIAPGVRVSGD
DIIIGKTTPIPPDTEELGQRTKYHTKRDASTPLRSTENGIVDQVLLTTNQ
EGLKFVKVRMRTTKVPQIGDKFASRHGQKGTIGVTYRHEDMPFSAEGIVP
DLIINPHAIPSRMTVAHLIECLLSKVGSIRGYEGDATPFTDLTVDAVSNL
LRDNGYQSRGFEVMYNGHTGKKLMAQVFFGPTYYQRLRHMVDDKIHARAR
GPVQVLTRQPVEGRSRDGGLRFGEMERDCMIAHGAAGFLKERLMEASDAF
RVHVCGICGLMSVIANLKKNQFECRSCKNKTNIYQLHIPYAAKLLFQELM
AMNIAPRLYTERSG
3D structure
PDB7xtd Structural basis of nucleosome disassembly and reassembly by RNAPII elongation complex with FACT.
ChainB
Resolution3.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B D498 G499 D462 G463
BS02 rna B Q776 R879 K886 H887 K979 K987 H1097 R1124 Q718 R821 K828 H829 K921 K929 H1039 R1066
BS03 dna B R497 T791 M792 R1122 R1129 M1133 R461 T733 M734 R1064 R1071 M1075
BS04 ZN B C1163 C1166 C1182 C1185 C1105 C1108 C1124 C1127
Gene Ontology
Molecular Function
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
GO:0140727 siRNA-mediated pericentric heterochromatin formation
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005654 nucleoplasm
GO:0005665 RNA polymerase II, core complex
GO:0005721 pericentric heterochromatin

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7xtd, PDBe:7xtd, PDBj:7xtd
PDBsum7xtd
PubMed35981082
UniProtC4QZQ7

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