Structure of PDB 7xnm Chain B

Receptor sequence
>7xnmB (length=726) Species: 9823 (Sus scrofa) [Search protein sequence]
RTYTLTDYLKSTFRVKFYTLQWISDHEYLYKQENNILLFNAEYGNSSIFL
ENSTFDELGYSTNDYSVSPDRQFILFEYNYVKQWRHSYTASYDIYDLNKR
QLITEERIPNNTQWITWSPVGHKLAYVWNNDIYVKNEPNLSSQRITWTGK
ENVIYNGVTDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSF
YSDESLQYPKTVRIPYPKAGAENPTVKFFVVDTRTLSPNASVTSYQIVPP
ASVLIGDHYLCGVTWVTEERISLQWIRRAQNYSIIDICDYDESTGRWISS
VARQHIEISTTGWVGRFRPAEPHFTSDGNSFYKIISNEEGYKHICHFQTD
KSNCTFITKGAWEVIGIEALTSDYLYYISNEHKGMPGGRNLYRIQLNDYT
KVTCLSCELNPERCQYYSASFSNKAKYYQLRCFGPGLPLYTLHSSSSDKE
LRVLEDNSALDKMLQDVQMPSKKLDVINLHGTKFWYQMILPPHFDKSKKY
PLLIEVYAGPCSQKVDTVFRLSWATYLASTENIIVASFDGRGSGYQGDKI
MHAINRRLGTFEVEDQIEATRQFSKMGFVDDKRIAIWGWSYGGYVTSMVL
GAGSGVFKCGIAVAPVSKWEYYDSVYTERYMGLPTPEDNLDYYRNSTVMS
RAENFKQVEYLLIHGTADDNVHFQQSAQLSKALVDAGVDFQTMWYTDEDH
GIASNMAHQHIYTHMSHFLKQCFSLP
3D structure
PDB7xnm Structure of porcine dipeptidyl peptidase 4 inhibitory peptide complex
ChainB
Resolution3.58 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.14.5: dipeptidyl-peptidase IV.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B E205 Y547 S630 Y631 Y662 Y666 E165 Y507 S590 Y591 Y622 Y626
Gene Ontology
Molecular Function
GO:0002020 protease binding
GO:0004177 aminopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005102 signaling receptor binding
GO:0008236 serine-type peptidase activity
GO:0008239 dipeptidyl-peptidase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0006508 proteolysis
GO:0007155 cell adhesion
GO:0008284 positive regulation of cell population proliferation
GO:0010716 negative regulation of extracellular matrix disassembly
GO:0031295 T cell costimulation
GO:0043542 endothelial cell migration
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016324 apical plasma membrane
GO:0030027 lamellipodium
GO:0030139 endocytic vesicle
GO:0031258 lamellipodium membrane
GO:0042995 cell projection
GO:0045121 membrane raft
GO:0070161 anchoring junction

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7xnm, PDBe:7xnm, PDBj:7xnm
PDBsum7xnm
PubMed
UniProtP22411|DPP4_PIG Dipeptidyl peptidase 4 (Gene Name=DPP4)

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