Structure of PDB 7xmv Chain B

Receptor sequence
>7xmvB (length=307) Species: 511145 (Escherichia coli str. K-12 substr. MG1655) [Search protein sequence]
DMKLFAGNATPELAQRIANRLYTSLGDAAVGRFSDGEVSVQINENVRGGD
IFIIQSTCAPTNDNLMELVVMVDALRRASAGRITAVIPYFGYARQDRRVR
SARVPITAKVVADFLSSVGVDRVLTVDLHAEQIQGFFDVPVDNVFGSPIL
LEDMLQLNLDNPIVVSPDIGGVVRARAIAKLLNDTDMAIIDKRRQVMHII
GDVAGRDCVLVDDMIDTGGTLCKAAEALKERGAKRVFAYATHPIFSGNAA
NNLRNSVIDEVVVCDTIPLSDEIKSLPNVRTLTLSGMLAEAIRRISNEES
ISAMFEH
3D structure
PDB7xmv Filamentation modulates allosteric regulation of PRPS.
ChainB
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.6.1: ribose-phosphate diphosphokinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP B F35 D37 E39 F33 D35 E37
BS02 AMP B R99 V101 R102 R97 V99 R100
BS03 HSX B D220 D221 M222 D224 T225 G227 T228 D212 D213 M214 D216 T217 G219 T220
BS04 ADP B R96 R99 H131 R94 R97 H129
BS05 AMP B E133 F147 S149 V175 A179 E131 F145 S147 V173 A177
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004749 ribose phosphate diphosphokinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0042301 phosphate ion binding
GO:0042802 identical protein binding
GO:0043531 ADP binding
GO:0046872 metal ion binding
Biological Process
GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process
GO:0006164 purine nucleotide biosynthetic process
GO:0009156 ribonucleoside monophosphate biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0016310 phosphorylation
GO:0034214 protein hexamerization
GO:0044249 cellular biosynthetic process
Cellular Component
GO:0002189 ribose phosphate diphosphokinase complex
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7xmv, PDBe:7xmv, PDBj:7xmv
PDBsum7xmv
PubMed35736577
UniProtP0A717|KPRS_ECOLI Ribose-phosphate pyrophosphokinase (Gene Name=prs)

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