Structure of PDB 7xlf Chain B

Receptor sequence
>7xlfB (length=283) Species: 627192 (Sphingobium sp. SYK-6) [Search protein sequence]
LDKAALSRLFTDYSLEITPKDVEALENAAHMIPPGTLISVTFLPGAEYED
RARAAKRIQELGFRPVPHLSARRLIDEADLRTYLDMLKGVIDLKHVFVIA
GDPNEPLGIYEDALALIDSGILKEYGIEHCGISGYPEGHPDITDEKLAKA
MHDKVASLKRQGIDYSIMTQFGFDAEPVLEWLKQIRSEGIDGPVRIGLAG
PASIKTLLRFAARCGVGTSAKVVKKYGLSITSLIGSAGPDPVIEDLTPVL
GPEHGQVHLHFYPFGGLVKTNEWIVNFKGKQGI
3D structure
PDB7xlf Crystal structural of methylenetetrahydrofolate reductase from Sphingobium sp. SYK-6
ChainB
Resolution1.85 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 1.5.1.54: methylenetetrahydrofolate reductase (NADH).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD B F47 L48 H73 R77 R78 F102 I104 A105 G106 D117 A118 S138 Y140 H144 I147 K151 A155 F42 L43 H68 R72 R73 F97 I99 A100 G101 D112 A113 S133 Y135 H139 I142 K146 A150
BS02 C2F B E21 L48 Q175 F215 C219 Y267 F269 E16 L43 Q170 F210 C214 Y262 F264
Gene Ontology
Molecular Function
GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity
GO:0016491 oxidoreductase activity
GO:0071949 FAD binding
GO:0106312 methylenetetrahydrofolate reductase (NADH) activity
Biological Process
GO:0006555 methionine metabolic process
GO:0009086 methionine biosynthetic process
GO:0035999 tetrahydrofolate interconversion
Cellular Component
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7xlf, PDBe:7xlf, PDBj:7xlf
PDBsum7xlf
PubMed
UniProtG2IQS8|METF_SPHSK 5,10-methylenetetrahydrofolate reductase (Gene Name=metF)

[Back to BioLiP]