Structure of PDB 7xeb Chain B

Receptor sequence

>7xebB (length=533) Species: 673 (Grimontia hollisae)

EQCDLSQFQTTSSNQLMAAIRQQGASCVNALFSADTGVQEAAFSSNHMYN
VAQYTRTLAQQYAGGGSDELEALYLYLRAGYYAEFYNSNITFLSWVTPAV
KGAVDAFVQNAHFYDNGDAHGKVLNEVIITMDSAGLQHAYLDVVTQWLTR
WNAQYAEHWYMRNAVNGVFTLLFGGQWNNQYTSLIGEQTALVTALQAFAL
DRTKVNSPTEFMAANAARELGRLARYTDATIAPKVTEGLTAIFGQYPSYG
DGDAIWLGAADTASYYADCSQFNICGFEDALRDAALNQTFICSDTIKIRS
QDMSQAQHLAACDKMAYEESFFHTTLETGNQPVADDHNTQLQVNIFNSDT
DYGKYAGPIFGIDTNNGGMYLEGNPANVGNIPNFIAYEASYANPDHFVWN
LEHEYVHYLDGRFNMYGDFGTPTELVVWWSEGVAEYVSRVNDNPQAIATI
QDGSTYTLAQVFDTTYDGFDVDRIYRWGYLAVRFMFERHPDEVQRMLSAT
RQGRWAEYKAIISGWANQYQSEFAQWTEALAKG

3D structure

• PDB: 7xeb Crystal structure of Grimontia hollisae collagenase provides insights into its novel substrate specificity toward collagen.
• Chain: B
• Resolution: 2.39 Å

Enzymatic activity

• Enzyme Commision number: 3.4.24.3: microbial collagenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	G457 M458 Y459 E493 H496 F508 E520 Y555 F558 Y564	G368 M369 Y370 E404 H407 F419 E431 Y466 F469 Y475
BS02	peptide	B	N455 G456 G457 W488 N489 H492 E493 Y564	N366 G367 G368 W399 N400 H403 E404 Y475
BS03	peptide	B	F121 R167 Y171 F174 Y175 E215 I218 D221 S222	F32 R78 Y82 F85 Y86 E126 I129 D132 S133
BS04	peptide	B	F262 N304 E308 R311 Y354	F173 N215 E219 R222 Y265
BS05	ZN	B	H492 H496 E520	H403 H407 E431
BS06	CA	B	E461 G500 M504 G506	E372 G411 M415 G417
BS07	CA	B	D391 N436 E477	D302 N347 E388
BS08	CA	B	T538 D541 S543	T449 D452 S454
BS09	CA	B	E173 I179	E84 I90

Gene Ontology

Molecular Function

• GO:0004222 metalloendopeptidase activity
• GO:0008270 zinc ion binding

Biological Process

• GO:0006508 proteolysis

Cellular Component

• GO:0005576 extracellular region

External links

• PDB: RCSB:7xeb, PDBe:7xeb, PDBj:7xeb
• PDBsum: 7xeb
• PubMed: 35679897
• UniProt: F7IZI6