Structure of PDB 7x6i Chain B

Receptor sequence

>7x6iB (length=687) Species: 9606 (Homo sapiens)

DRIPLQIVRAETELSAEEKAFLNAVEKGDYATVKQALQEAEIYYNVNINC
MDPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELL
LSYRRPSGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKLLVQKR
VTIPRPHQIRCNCVECVSSSEVDSLRHSRSRLNIYKALASPSLIALSSED
PILTAFRLGWELKELSKVENEFKAEYEELSQQCKLFAKDLLDQARSSREL
EIILNHRDDLAKLKVAIKYHQKEFVAQPNCQQLLATLWYDGFPGWRRKHW
VVKLLTCMTIGFLFPMLSIAYLISPRSNLGLFIKKPFIKFICHTASYLTF
LFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIKEMWDGGF
TEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLI
AEALFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLV
LLAFANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFW
SVFGLLNLYVTNVKARHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNS
YQLIADHADIEWKFARTKLWMSYFDEGGTLPPPFNIIPDSLIQNQHYQEV
IRNLVKRYVAAMIRNSKTHEGLTEENFKELKQDISSF

3D structure

• PDB: 7x6i Molecular architecture of the G alpha i -bound TRPC5 ion channel.
• Chain: B
• Resolution: 3.93 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	YZY	B	L514 L521 Y524 Q573 F576	L487 L494 Y497 Q546 F549
BS02	Y01	B	Y316 A499 N500	Y289 A472 N473
BS03	ZN	B	H172 C181	H157 C166
BS04	CA	B	E418 E421 N436 D439	E391 E394 N409 D412
BS05	YZY	B	F599 V610 I611	F572 V583 I584

Gene Ontology

Molecular Function

• GO:0005216 monoatomic ion channel activity
• GO:0005262 calcium channel activity

Biological Process

• GO:0006811 monoatomic ion transport
• GO:0055085 transmembrane transport
• GO:0070588 calcium ion transmembrane transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:7x6i, PDBe:7x6i, PDBj:7x6i
• PDBsum: 7x6i
• PubMed: 37137991
• UniProt: Q9UL62|TRPC5_HUMAN Short transient receptor potential channel 5 (Gene Name=TRPC5)