Structure of PDB 7wnh Chain B

Receptor sequence
>7wnhB (length=313) Species: 9606 (Homo sapiens) [Search protein sequence]
LCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRR
RNRCQYCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSPVSLISALVRAHVD
SNPAMTSLDYSRFQANPDYDTQHIQQFYDLLTGSMEIIRGWAEKIPGFAD
LPKADQDLLFESAFLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVRGF
GEWIDSIVEFSSNLQNMNIDISAFSCIAALAMVTERHGLKEPKRVEELQN
KIVNCLKDHVTFNNGGLNRPNYLSKLLGKLPELRTLCTQGLQRIFYLKLE
DLVPPPAIIDKLF
3D structure
PDB7wnh Integrative analysis reveals structural basis for transcription activation of Nurr1 and Nurr1-RXR alpha heterodimer.
ChainB
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B Q273 H274 Y275 V332 V333 R334 G340 R342 G343 Q12 H13 Y14 V71 V72 R73 G79 R81 G82
BS02 dna B E281 R289 R312 N313 R319 R341 R342 G343 R344 P346 E20 R28 R51 N52 R58 R80 R81 G82 R83 P85
BS03 ZN B C266 C280 C283 C5 C19 C22
BS04 ZN B C305 C315 C44 C54
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0004879 nuclear receptor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7wnh, PDBe:7wnh, PDBj:7wnh
PDBsum7wnh
PubMed36442107
UniProtP43354|NR4A2_HUMAN Nuclear receptor subfamily 4 group A member 2 (Gene Name=NR4A2)

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