Structure of PDB 7wj4 Chain B

Receptor sequence
>7wj4B (length=556) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
MKYILVTGGVISGVGKGVIASSFGTLLKSCGLDVTSIKIDPYINIDAGTF
SPYEHGEVYVLDDGAEVDLDLGNYERFLDVTLHRDNNITTGKIYKLVIEK
ERTGEYLGKTVQVVPHITDAIQEWVERVAQTPVQGSSKPQVCIVELGGTI
GDIEGMPFVEAFRQFQFRVKRENFCLAHVSLVPLPKATGEPKTKPTQSSV
RELRGCGLSPDLIVCRSEKPIGLEVKEKISNFCHVGPDQVICIHDLNSIY
HVPLLMEQNGVIEYLNERLQLNIDMSKRTKCLQQWRDLARRTETVRREVC
IAVVGKYTKFTDSYASVVKALQHAALAVNRKLELVFIESCLLEEETLHSE
PSKYHKEWQKLCDSHGILVPGGFGSRGMEGKIRACQWARENQKPLLGICL
GLQAAVIEFARNKLGLKDANTTEIDPNTANALVIDMPEHHTGQLGGTMRL
GKRITVFSDGPSVIRQLYGNPKSVQERHRHRYEVNPKYVHLLEEQGMRFV
GTDVDKTRMEIIELSGHPYFVATQYHPEYLSRPLKPSPPFLGLILASVDR
LNQYIQ
3D structure
PDB7wj4 Structural basis for ligand binding modes of CTP synthase.
ChainB
Resolution3.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.4.2: CTP synthase (glutamine hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP B F50 S51 R376 F50 S51 R376
BS02 ATP B G13 G15 K16 G17 V18 D70 L246 G13 G15 K16 G17 V18 D70 L246
BS03 GGL B G372 F373 C399 L400 H480 R481 Y482 G372 F373 C399 L400 H480 R481 Y482
BS04 MG B D70 E145 D70 E145
BS05 UTP B K192 T193 K194 K228 K192 T193 K194 K228
BS06 UTP B S12 Y42 G148 E154 S12 Y42 G148 E154
Gene Ontology
Molecular Function
GO:0003883 CTP synthase activity
Biological Process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0006241 CTP biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7wj4, PDBe:7wj4, PDBj:7wj4
PDBsum7wj4
PubMed34301892
UniProtQ9VUL1|PYRG_DROME CTP synthase (Gene Name=Ctps)

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