Structure of PDB 7wi8 Chain B

Receptor sequence
>7wi8B (length=723) Species: 9606 (Homo sapiens) [Search protein sequence]
REIKIEGDLVLGGLFPINERINEDRGIQRLEAMLFAIDEINKDDYLLPGV
KLGVHILDTCSRDTYALEQSLEFVRASLLIAGVIGGSYSSVSIQVANLLR
LFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTY
VSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGSYDSVIRELLQKPN
ARVVVLFMRSDDSRELIAAASRANASFTWVASDGWGAQESIIKGSEHVAY
GAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLLAIDS
SNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLY
KDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSYL
KVGHWAETLSLDVNSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWIC
IPCEPYEYLADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPV
TIACLGFMCTCMVVTVFIKHNNTPLVKASGRELCYILLFGVGLSYCMTFF
FIAKPSPVICALRRLGLGSSFAICYSALLTKTNCIARQVFICLGLILVQI
VMVSVWLILEAPGTRRYTLAEKRETVILKCNVKDSSMLISLTYDVILVIL
CTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQT
TTMCISVSLSGFVVLGCLFAPKV
3D structure
PDB7wi8 Structural basis of the activation of metabotropic glutamate receptor 3.
ChainB
Resolution4.17 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Z99 B Y150 S151 T174 Y222 Y88 S89 T112 Y160
Gene Ontology
Molecular Function
GO:0001641 group II metabotropic glutamate receptor activity
GO:0004930 G protein-coupled receptor activity
GO:0005246 calcium channel regulator activity
GO:0008066 glutamate receptor activity
GO:0097110 scaffold protein binding
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007194 negative regulation of adenylate cyclase activity
GO:0007196 adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway
GO:0007216 G protein-coupled glutamate receptor signaling pathway
GO:0007268 chemical synaptic transmission
GO:0010467 gene expression
GO:0033554 cellular response to stress
GO:0051966 regulation of synaptic transmission, glutamatergic
GO:0099170 postsynaptic modulation of chemical synaptic transmission
Cellular Component
GO:0005886 plasma membrane
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0030424 axon
GO:0042734 presynaptic membrane
GO:0043005 neuron projection
GO:0043197 dendritic spine
GO:0045211 postsynaptic membrane
GO:0097449 astrocyte projection
GO:0098978 glutamatergic synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7wi8, PDBe:7wi8, PDBj:7wi8
PDBsum7wi8
PubMed35236939
UniProtQ14832|GRM3_HUMAN Metabotropic glutamate receptor 3 (Gene Name=GRM3)

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