Structure of PDB 7wf5 Chain B

Receptor sequence
>7wf5B (length=265) Species: 9031 (Gallus gallus) [Search protein sequence]
GLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMS
PEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGE
MGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVA
DFGLAFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVN
REVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLED
YFTSTEPQYQPGENL
3D structure
PDB7wf5 Structural study of ponatinib in inhibiting SRC kinase.
ChainB
Resolution1.798 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0LI B A293 K295 E310 M314 V323 I336 T338 M341 V383 H384 L393 V402 A403 D404 F405 A40 K42 E57 M61 V70 I83 T85 M88 V130 H131 L140 V149 A150 D151 F152
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7wf5, PDBe:7wf5, PDBj:7wf5
PDBsum7wf5
PubMed35151199
UniProtP00523|SRC_CHICK Proto-oncogene tyrosine-protein kinase Src (Gene Name=SRC)

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