Structure of PDB 7wdc Chain B

Receptor sequence

>7wdcB (length=460) Species: 1140 (Synechococcus elongatus PCC 7942 = FACHB-805) [Search protein sequence]

IAKMRTMIEGFDDISHGGLPIGRSTLVSGTSGTGKTLFSIQFLYNGIIEF
DEPGVFVTFEETPQDIIKNARSFGWDLAKLVDEGKLFILDALSALIERIN
YAIQKYRARRVSIDSVTSVFQQYDASSVVRRELFRLVARLKQIGATTVMT
TERIEEYGPIARYGVEEFVSDNVVILRNVLEGERRRRTLEILKLRGTSHM
KGEYPFTITDHGINIFPLQRSSNVRVSSGVVRLDEMCGGGFFKDSIILAT
GATGTGKTLLVSRFVENACANKERAILFAYEESRAQLLRNAYSWGMDFEE
MERQNLLKIVCAYPESAGLEDHLQIIKSEINDFKPARIAIDSLSALARGV
SNNAFRQFVIGVTGYAKQEEITGLFTNTSDQWMGAHSITDSHISTITDTI
ILLQYVEIRGEMSRAINVFKMRGSWHDKAIREFMISDKGPDIKDSFRNFE
RIISGSPTRI

3D structure

PDB

7wdc Highly sensitive tryptophan fluorescence probe for detecting rhythmic conformational changes of KaiC in the cyanobacterial circadian clock system.

Chain

Resolution

2.84 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.11.1: non-specific serine/threonine protein kinase.
3.6.4.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	ATP	B	K224 L225 R226 T228 S229 H230	K193 L194 R195 T197 S198 H199
BS02	ATP	B	K457 M458 R459 G460 S461 H463	K420 M421 R422 G423 S424 H426
BS03	ATP	B	S48 T50 G51 K52 T53 L54 S89 F90 I239	S31 T33 G34 K35 T36 L37 S72 F73 I208
BS04	ATP	B	T290 G291 T292 G293 K294 T295 L296 W331 I472	T253 G254 T255 G256 K257 T258 L259 W294 I435
BS05	MG	B	T53 D145	T36 D114

Gene Ontology

	Molecular Function
GO:0000287	magnesium ion binding
GO:0003677	DNA binding
GO:0004674	protein serine/threonine kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0016887	ATP hydrolysis activity
GO:0042802	identical protein binding
GO:0044024	histone H2AS1 kinase activity
GO:0046872	metal ion binding
GO:0106310	protein serine kinase activity

	Biological Process
GO:0006338	chromatin remodeling
GO:0006355	regulation of DNA-templated transcription
GO:0007623	circadian rhythm
GO:0009649	entrainment of circadian clock
GO:0016310	phosphorylation
GO:0042752	regulation of circadian rhythm
GO:0042754	negative regulation of circadian rhythm
GO:0048511	rhythmic process
GO:0070297	regulation of phosphorelay signal transduction system

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:7wdc, PDBe:7wdc, PDBj:7wdc
PDBsum	7wdc
PubMed	35771042
UniProt	Q79PF4\|KAIC_SYNE7 Circadian clock oscillator protein KaiC (Gene Name=kaiC)

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