Structure of PDB 7wbt Chain B

Receptor sequence

>7wbtB (length=899) Species: 9913 (Bos taurus)

QKINPYRSHMKQKFQVLWEKEPCLLVPEDFYEETTKIEYELLSTVYLDAE
SSPTVVLHGPEGIGKTTFLRKVMLEWAKGNLWRDRFSFVFFLTGREMNGV
TDMSLVELLSRDWPESSEPIEDIFSQPERILFILDGMEELKFDLDCNADL
CEDWEQPQSMQVVLQSLLQKQMLPECSLLLALSKMGMRKNYSLLKHMKCI
FLLGFSEHQRKLYFSHYFQEKDASSRAFSFVREKSSLFVLCQSPFLCWLV
CTSLKCQLEKGEDLELDSETITGLYVSFFTKVFRSGSETCPLKQRRARLK
SLCTLAAEGMWTCTFLFCPEDLRRNGVSESDTSMWLDMKLLHRSGDCLAF
IHTCIQEFCAAMFYMFTRPKDPPHSVIGNVTQLITRAVSGHYSRLSWTAV
FLFVFSTERMTHRLETSFGFPLSKEIKQEITQSLDTLSQCDPNNVMMSFQ
ALFNCLFETQDPEFVAQVVNFFKDIDIYIGTKEELIICAACLRHCHSLQK
FHLCMEHVFPDESGCISNTIEKLTLWRDVCSAFAASEDFEILNLDNCRFD
EPSLAVLCRTLSQPVCKLRKFVCNFASNLANSLELFKVILHNPHLKHLNF
YGSSLSHMDARQLCEALKHPMCNIEELMLGKCDITGEACEDIASVLVHNK
KLNLLSLCENALKDDGVLVLCEALKNPDCALEALLLSHCCFSSAACDHLS
QVLLYNRSLTFLDLGSNVLKDEGVTTLCESLKHPSCNLQELWLMNCYFTS
VCCVDIATVLIHSEKLKTLKLGNNKIYDAGAKQLCKALKHPKCKLENLGL
EACELSPASCEDLASALTTCKSLTCVNLEWITLDYDGAAVLCEALVSLEC
SLQLLGLNKSSYDEEIKMMLTQVEEMNPNLIISHHLWTDDEGRRRGILV

3D structure

• PDB: 7wbt The structure of NLRP9 reveals a unique C-terminal region with putative regulatory function.
• Chain: B
• Resolution: 2.75 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ADP	B	P115 C116 Y124 G159 G161 K162 T163 T164 F302 P341 H449	P22 C23 Y31 G62 G64 K65 T66 T67 F205 P244 H352

Gene Ontology

Molecular Function

• GO:0005524 ATP binding

Biological Process

• GO:0006954 inflammatory response
• GO:0045087 innate immune response
• GO:0050727 regulation of inflammatory response

Cellular Component

• GO:0005737 cytoplasm
• GO:0061702 canonical inflammasome complex

External links

• PDB: RCSB:7wbt, PDBe:7wbt, PDBj:7wbt
• PDBsum: 7wbt
• PubMed: 35090055
• UniProt: Q288C4|NLRP9_BOVIN NACHT, LRR and PYD domains-containing protein 9 (Gene Name=NLRP9)