Structure of PDB 7w5i Chain B

Receptor sequence
>7w5iB (length=339) Species: 63577 (Trichoderma atroviride) [Search protein sequence]
LSGERREIIRRALNKKILVPNILELMPAWPSEFQPNIDEVNVEIDEWLKT
VNVAKEKKLKHRARGNYTLLAGIYYPHCRKEKMLALSQFLYWIFFWDDEI
DREGTILCCAETNKCINDCLGPEPNYTPPPGSRGTVEMLYPILRDLRAGL
SPVSTMRLKQELHDYVNGVKNQHLPNPWDHFQMRVDDVGVIPSITQNEYA
MDFTLPDWIRRHEAMEEIVLQCTKLTILLNEILSLQKEFRVSQLENLCLL
FMNTYDMSIEQSIHKVLGLLKDHYKICIEAEARLPWSTTDEKLNNNIREY
IRGCQRLATGTACWSYNCERYFKLSQLNDQQELLLDLSR
3D structure
PDB7w5i Structural insights into the cyclization of unusual brasilane-type sesquiterpenes.
ChainB
Resolution2.13 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 4.2.3.-
4.2.3.104: alpha-humulene synthase.
4.2.3.137: (E)-2-epi-beta-caryophyllene synthase.
4.2.3.157: (+)-isoafricanol synthase.
4.2.3.182: pristinol synthase.
4.2.3.57: (-)-beta-caryophyllene synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FPP B R230 G235 V236 N276 E284 R366 Y367 R184 G189 V190 N230 E238 R320 Y321
BS02 MG B N276 S280 E284 N230 S234 E238
Gene Ontology
Molecular Function
GO:0016829 lyase activity
GO:0046872 metal ion binding
GO:0080016 (-)-E-beta-caryophyllene synthase activity
GO:0080017 alpha-humulene synthase activity

View graph for
Molecular Function
External links
PDB RCSB:7w5i, PDBe:7w5i, PDBj:7w5i
PDBsum7w5i
PubMed35504416
UniProtA0A5S9I252|TATC6_HYPAT Terpene cyclase 6 (Gene Name=tatc6)

[Back to BioLiP]