Structure of PDB 7w3i Chain B

Receptor sequence
>7w3iB (length=399) Species: 9606 (Homo sapiens) [Search protein sequence]
PTRVGKKKKKTKGPDAASKLPLVTPHTQCRLKLLKLERIKDYLLMEEEFI
RNQEQMKPLEEKQEEERSKVDDLRGTPMSVGTLEEIIDDNHAIVSTSVGS
EHYVSILSFVDKDLLEPGCSVLLNHKVHAVIGVLMDDTDPLVTVMKVEKA
PQETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPG
TGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAP
SIVFIDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIM
ATNRIETLDPALIRPGRIDRKIEFPLPDEKTKKRIFQIHTSRMTLADDVT
LDDLIMAKDDLSGADIKAICTEAGLMALRERRMKVTNEDFKKSKENVLY
3D structure
PDB7w3i USP14-regulated allostery of the human proteasome by time-resolved cryo-EM.
ChainB
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP B D317 R343 D288 R314
BS02 ADP B I187 G188 P228 G229 T230 G231 K232 T233 L234 I364 H368 A393 K396 I158 G159 P199 G200 T201 G202 K203 T204 L205 I335 H339 A364 K367
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0036402 proteasome-activating activity
Biological Process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:1901800 positive regulation of proteasomal protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005838 proteasome regulatory particle
GO:0008540 proteasome regulatory particle, base subcomplex
GO:0016020 membrane
GO:0022624 proteasome accessory complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7w3i, PDBe:7w3i, PDBj:7w3i
PDBsum7w3i
PubMed35477760
UniProtP62191|PRS4_HUMAN 26S proteasome regulatory subunit 4 (Gene Name=PSMC1)

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