Structure of PDB 7w1y Chain B

Receptor sequence
>7w1yB (length=651) Species: 9606 (Homo sapiens) [Search protein sequence]
AGTVVLDDVELREAQRDYLDFLDDEEDQGIYQSKVRELISDNQYRLIVNV
NDLRRKNEKRANRLLNNAFEELVAFQRALKDFVASIDATYAKQYEEFYVG
LEGSFGSKHVSPRTLTSCFLSCVVCVEGIVTKCSLVRPKVVRSVHYCPAT
KKTIERRYSDLTTLVAFPSSSVYPTKDEENNPLETEYGLSVYKDHQTITI
QEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVVGTYRCLPGKKGGY
TSGTFRTVLIACNVKQMSKDAQPSFSAEDIAKIKKFSKTRSKDIFDQLAK
SLAPSIHGHDYVKKAILCLLLGGVERDLENGSHIRGDINILLIGDPSVAK
SQLLRYVLCTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLA
DRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAA
ANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHV
LRMHRYRAPGEQDGDAMPLGSAVDILATDDPNFSQIYEKHDNLLHGTKKK
KEKMVSAAFMKKYIHVAKIIKPVLTQESATYIAEEYSRLRSQDSMSSDTA
RTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYFKKVL
E
3D structure
PDB7w1y The human pre-replication complex is an open complex.
ChainB
Resolution2.59 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B K247 S253 T383 T384 K246 S252 T382 T383
BS02 ATP B I307 H308 P347 S348 V349 A350 K351 S352 Q353 N453 V501 I306 H307 P346 S347 V348 A349 K350 S351 Q352 N452 V500
BS03 ATP B E427 R478 R616 E619 E426 R477 R608 E611
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006139 nucleobase-containing compound metabolic process
GO:0006260 DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0006271 DNA strand elongation involved in DNA replication
GO:0030174 regulation of DNA-templated DNA replication initiation
GO:0032508 DNA duplex unwinding
GO:1902975 mitotic DNA replication initiation
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005658 alpha DNA polymerase:primase complex
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0016020 membrane
GO:0042555 MCM complex
GO:0048471 perinuclear region of cytoplasm
GO:0071162 CMG complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7w1y, PDBe:7w1y, PDBj:7w1y
PDBsum7w1y
PubMed36608662
UniProtP25205|MCM3_HUMAN DNA replication licensing factor MCM3 (Gene Name=MCM3)

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