Structure of PDB 7vzs Chain B

Receptor sequence

>7vzsB (length=568) Species: 5062 (Aspergillus oryzae)

KNTTTYDYIVVGGGTSGLVVANRLSENPDVSVLLLEAGASVFNNPDVTNA
NGYGLAFGSAIDWQYQSINQSYAGGKQQVLRAGKALGGTSTINGMAYTRA
EDVQIDVWQKLGNEGWTWKDLLPYYLKSENLTAPTSSQVAAGAAYNPAVN
GKEGPLKVGWSGSLASGNLSVALNRTFQAAGVPWVEDVNGGKMRGFNIYP
STLDVDLNVREDAARAYYFPYDDRKNLHLLENTTANRLFWKNGSAEEAIA
DGVEITSADGKVTRVHAKKEVIISAGALRSPLILELSGVGNPTILKKNNI
TPRVDLPTVGENLQDQFNNGMAGEGYGVLAGASTVTYPSISDVFGNETDS
IVASLRSQLSDYAAATVKVSNGHMKQEDLERLYQLQFDLIVKDKVPIAEI
LFHPGGGNAVSSEFWGLLPFARGNIHISSNDPTAPAAINPNYFMFEWDGK
SQAGIAKYIRKILRSAPLNKLIAKETKPGLSEIPATAADEKWVEWLKANY
RSNFHPVGTAAMMPRSIGGVVDNRLRVYGTSNVRVVDASVLPFQVCGHLV
STLYAVAERASDLIKEDA

3D structure

• PDB: 7vzs Conformational change of catalytic residue in reduced enzyme of FAD-dependent Glucose Dehydrogenase at pH6.5
• Chain: B
• Resolution: 1.8 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	B	G15 T16 S17 E37 A38 Y54 F58 W64 R82 G84 G89 T90 N94 G95 M96 A97 T235 A236 A276 R280 F505 H549 L550 V551 L554	G14 T15 S16 E36 A37 Y53 F57 W63 R81 G83 G88 T89 N93 G94 M95 A96 T234 A235 A275 R279 F504 H548 L549 V550 L553
BS02	DGO	B	Y54 E414 R502 N504 H549	Y53 E413 R501 N503 H548
BS03	DGO	B	Y9 L25 N28 K566	Y8 L24 N27 K565
BS04	DGO	B	I352 Q359 E447 W448 K451	I351 Q358 E446 W447 K450
BS05	DGO	B	A145 Y146	A144 Y145
BS06	DGO	B	A142 S167 S171 N175	A141 S166 S170 N174

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0016491 oxidoreductase activity
• GO:0016614 oxidoreductase activity, acting on CH-OH group of donors
• GO:0050660 flavin adenine dinucleotide binding

External links

• PDB: RCSB:7vzs, PDBe:7vzs, PDBj:7vzs
• PDBsum: 7vzs
• UniProt: A0A1S9DW10