Structure of PDB 7vup Chain B

Receptor sequence
>7vupB (length=296) Species: 9606 (Homo sapiens) [Search protein sequence]
TADGPYLVIVEQPKQRGFRFRYGCEGPSHGGLPGASSEKGRKTYPTVKIC
NYEGPAKIEVDLVTHSDPPRAHAHSLVGKQCSELGICAVSVGPKDMTAQF
NNLGVLHVTKKNMMGTMIQKLQRQRLRSRPQGLTEAEQRELEQEAKELKK
VMDLSIVRLRFSAFLRASDGSFSLPLKPVISQPIHDSKSPGASNLKISRM
DKTAGSVRGGDEVYLLCDKVQKDDIEVRFYEDDENGWQAFGDFSPTDVHK
QYAIVFRTPPYHKMKIERPVTVFLQLKRKRGGDVSDSKQFTYYPLV
3D structure
PDB7vup Structures of NF-kappa B p52 homodimer-DNA complexes rationalize binding mechanisms and transcription activation.
ChainB
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B R52 R54 S61 H62 G63 K75 K221 R19 R21 S28 H29 G30 K42 K188
BS02 dna B Y55 C57 H62 T142 K143 K221 P223 Q284 Y22 C24 H29 T109 K110 K188 P190 Q251
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7vup, PDBe:7vup, PDBj:7vup
PDBsum7vup
PubMed36779700
UniProtQ00653|NFKB2_HUMAN Nuclear factor NF-kappa-B p100 subunit (Gene Name=NFKB2)

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