Structure of PDB 7vjl Chain B

Receptor sequence
>7vjlB (length=266) Species: 9606 (Homo sapiens) [Search protein sequence]
DLPLDPLWEFPRDRLVLGKPLGFGQVVRAEAFGMDPARPDQASTVAVKML
KDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAK
GNLREFLRARRPPGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNV
LVTEDNVMKIADFGPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGG
SPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFK
QLVEALDKVLLAVSEE
3D structure
PDB7vjl Characterization of an aromatic trifluoromethyl ketone as a new warhead for covalently reversible kinase inhibitor design.
ChainB
Resolution2.90017 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7IF B L473 V481 R483 T499 V500 A501 C552 A553 A554 L619 L21 V26 R28 T44 V45 A46 C97 A98 A99 L151
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7vjl, PDBe:7vjl, PDBj:7vjl
PDBsum7vjl
PubMed34670167
UniProtP22455|FGFR4_HUMAN Fibroblast growth factor receptor 4 (Gene Name=FGFR4)

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