Structure of PDB 7vgf Chain B

Receptor sequence
>7vgfB (length=550) Species: 9606 (Homo sapiens) [Search protein sequence]
DRPDLRARVAISLGFLGGAKAMNIVVPFMFKYAVDSLNQMVATMATAVLI
GYGVSRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLGFHLSR
QTGALSKAIDRGTRGISFVLSALVFNLLPIMFEVMLVSGVLYYKCGAQFA
LVTLGTLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVK
YFNNERYEAQRYDGFLKTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMV
LASQGIVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALIDMNTL
FTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHFEYIEGQKVLSGISFE
VPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESL
RRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRM
PHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITE
ETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLL
3D structure
PDB7vgf Cryo-EM structure of AMP-PNP-bound human mitochondrial ATP-binding cassette transporter ABCB7.
ChainB
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP B Y481 G508 G510 K511 S512 Q553 T636 Y337 G364 G366 K367 S368 Q409 T492
BS02 MG B S512 Q553 S368 Q409
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0015232 heme transmembrane transporter activity
GO:0016887 ATP hydrolysis activity
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0140359 ABC-type transporter activity
GO:0140481 ABC-type iron-sulfur cluster transporter activity
Biological Process
GO:0006879 intracellular iron ion homeostasis
GO:0015886 heme transport
GO:0016226 iron-sulfur cluster assembly
GO:0034755 iron ion transmembrane transport
GO:0055085 transmembrane transport
GO:0070455 positive regulation of heme biosynthetic process
GO:0140466 iron-sulfur cluster export from the mitochondrion
GO:1903331 positive regulation of iron-sulfur cluster assembly
GO:1903427 negative regulation of reactive oxygen species biosynthetic process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7vgf, PDBe:7vgf, PDBj:7vgf
PDBsum7vgf
PubMed
UniProtO75027|ABCB7_HUMAN Iron-sulfur clusters transporter ABCB7, mitochondrial (Gene Name=ABCB7)

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