Structure of PDB 7vba Chain B

Receptor sequence
>7vbaB (length=1123) Species: 9606 (Homo sapiens) [Search protein sequence]
SRWRNLPSGPSLKHLTDPSYGIPREQQKAALQELTRAHVESFNYAVHEGL
GLAVQAIPPFEFAFKDERISFTILDAVISPPTVPKGTICKEANVYPAECR
GRRSTYRGKLTADINWAVNGISKGIIKQFLGYVPIMVKSKLCNLRNLPPQ
ALIEHHEEAEEMGGYFIINGIEKVIRMLIMPRRNFPIAMIRPKWKTRGPG
YTQYGVSMHCVREEHSAVNMNLHYLENGTVMLNFIYRKELFFLPLGFALK
ALVSFSDYQIFQELIKGKEDDSFLRNSVSQMLRIVMEEGCSTQKQVLNYL
GECFRVKLNVPDWYPNEQAAEFLFNQCICIHLKSNTEKFYMLCLMTRKLF
ALAKGECMEDNPDSLVNQEVLTPGQLFLMFLKEKLEGWLVSIKIAFDKKA
QKTSVSMNTDNLMRIFTMGIDLTKPFEYLFATGNLRSKTGLGLLQDSGLC
VVADKLNFIRYLSHFRCVHRGADFAKMRTTTVRRLLPESWGFLCPVHTPD
GEPCGLMNHLTAVCEVVTQFVYTASIPALLCNLGVTPIDGAPHRSYSECY
PVLLDGVMVGWVDKDLAPGIADSLRHFKVLREKRIPPWMEVVLIPMTGKP
SLYPGLFLFTTPCRLVRPVQNLALGKEELIGTMEQIFMNVAIFEDEVFAG
VTTHQELFPHSLLSVIANFIPFSDHNQSPRNMYQCQMGKQTMGFPLLTYQ
DRSDNKLYRLQTPQSPLVRPSMYDYYDMDNYPIGTNAIVAVISYTGYDME
DAMIVNKASWERGFAHGSVYKSEFIDLSEKIKQGDSSLVFGIKPGDPRVL
QKLDDDGLPFIGAKLQYGDPYYSYLNLNTGESFVMYYKSKENCVVDNIKV
CSNDTGSGKFKCVCITMRVPRNPTIGDKFASRHGQKGILSRLWPAEDMPF
TESGMVPDILFNPHGFPSRMTIGMLIESMAGKSAALHGLCHDATPFIFSE
ENSALEYFGEMLKAAGYNFYGTERLYSGISGLELEADIFIGVVYYQRLRH
MVSDKFQVRTTGARDRVTNQPIGGRNVQGGIRFGEMERDALLAHGTSFLL
HDRLFNCSDRSVAHVCVKCGSLLSPLLEKPNRKYNCTLCSRSDTIDTVSV
PYVFRYFVAELAAMNIKVKLDVV
3D structure
PDB7vba Structure of the human RNA polymerase I elongation complex.
ChainB
Resolution2.89 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna B R180 V455 R464 Q690 Q694 K882 K890 H1004 R176 V451 R460 Q686 Q690 K878 K886 H1000
BS02 dna B N173 I175 A435 R482 N709 Q1011 R1029 R1036 N169 I171 A431 R478 N705 Q1007 R1025 R1032
BS03 dna B R482 T483 R478 T479
Gene Ontology
Molecular Function
GO:0001054 RNA polymerase I activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
GO:0071667 DNA/RNA hybrid binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006360 transcription by RNA polymerase I
GO:0007566 embryo implantation
GO:0009303 rRNA transcription
GO:0014029 neural crest formation
GO:0017126 nucleologenesis
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0001650 fibrillar center
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005736 RNA polymerase I complex
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7vba, PDBe:7vba, PDBj:7vba
PDBsum7vba
PubMed34671025
UniProtQ9H9Y6|RPA2_HUMAN DNA-directed RNA polymerase I subunit RPA2 (Gene Name=POLR1B)

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