Structure of PDB 7v9p Chain B

Receptor sequence

>7v9pB (length=845) Species: 405948 (Saccharopolyspora erythraea NRRL 2338)

PPNLTREQAEQRAALLEVQSYAIELDLSAVETFGSTTTVRFRSATPGAES
WIDLVAARVRSAVLNGVELDVSDYDESTGIRLPELAADNELVVHADCQYT
NTGEGLHRFIDPVDGGVYLYSQFETADAKRMFTCFDQPDLKATYQITVTA
PQDWKVISNAAGEVTDTGEGTRRHVFDTTKPMSTYLVALVAGPYAEWRDV
FPGDDGQDEIPLGIYCRASLAEHLDAERLFIETKQGFGFFHKAFGVPYPF
GKYDQCFVPEFNAGAMENAGCVTFLEDYVFRSRVTGYLYERRSETVLHEM
AHMWFGDLVTMRWWDDLWLNESFATWASVLAQVGATQYTNAWTTFASVEK
SWAYRQDQLPSTHPVAADIPDLQAVTYAKGASVLKQLVAYVGLENFLAGL
KVYFDRHAWGNATLDDLLVALEEASGRDLSWWSAQWLQTTGLNMLRPKLA
IDDEGRFTSFSVLQSPARPGAGEHRTHRLAIGIYDDDPATGELVRTHRVE
LDVTGERTEVPDLVGVHRGKLVLVNDDDLTYCTMRLDPQSLATLIDRIAD
IQESLPRALCWSTAWEMTREAELKARDFVSLVLGSSPTTGIGAESEIGVV
QRVLLQTQTALASYADPAWQPEGWRRFAGRLLELARAAEPGSDHQLAFVN
SLAGSVLGEEQISAMRGWLDGTAPLEGLTVDTDLRWGLLQALVAHGAAGE
AEIDAELERDQTATGRRRAERARSLIPTPEAKEKAWQRAVHDDQLPNAIS
DAIISGFQHPGQRELLASYVRRYFDEIDEVWHRRSSERAQPTVIGLFPSW
AVDEDTVAVADRWLEGEHAPALRRLVSEGRAGIVRALAAREFDRS

3D structure

• PDB: 7v9p Conformational remodeling enhances activity of lanthipeptide zinc-metallopeptidases.
• Chain: B
• Resolution: 1.8 Å

Enzymatic activity

• Enzyme Commision number: 3.4.11.2: membrane alanyl aminopeptidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	B	H306 H310 E329	H298 H302 E321

Gene Ontology

Molecular Function

• GO:0004177 aminopeptidase activity
• GO:0008237 metallopeptidase activity
• GO:0008270 zinc ion binding
• GO:0042277 peptide binding
• GO:0046872 metal ion binding
• GO:0070006 metalloaminopeptidase activity

Biological Process

• GO:0006508 proteolysis
• GO:0043171 peptide catabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:7v9p, PDBe:7v9p, PDBj:7v9p
• PDBsum: 7v9p
• PubMed: 35513512
• UniProt: A4F9D7