Structure of PDB 7v8o Chain B

Receptor sequence

>7v8oB (length=529) Species: 37926 (Thermocrispum municipale)

TPDLDAIVIGAGFGGIYMLHKLRNDLGLSVRVFEKGGGVGGTWYWNKYPG
AKSDTEGFVYRYSFDKELLREYDWTTRYLDQPDVLAYLEHVVERYDLARD
IQLNTEVTDAIFDEETELWRVTTAGGETLTARFLVTALGLLSRSNIPDIP
GRDSFAGRLVHTNAWPEDLDITGKRVGVIGTGSTGTQFIVAAAKMAEQLT
VFQRTPQYCVPSGNGPMDPDEVARIKQNFDSIWDQVRSSTVAFGFEESTV
EAMSVSESERQRVFQQAWDKGNGFRFMFGTFCDIATNPEANAAAAAFIRS
KIAEIVKDPETARKLTPTDLYAKRPLCNEGYYETYNRDNVSLVSLKETPI
EEIVPQGVRTSDGVVHELDVLVFATGFDAVDGNYRAMNLRGRDGRHINEH
WTEGPTSYLGVTKAGFPNMFMILGPNGPFTNTPPSIEAQVEWISDLIDKA
TREGLTTVEPTADAEREWTETCAEIANMTLFPKADSWIFGANIPGKRHAV
MFYLGGLGNYRRQLADVADGGYRGFQLRG

3D structure

• PDB: 7v8o Biocatalytic Baeyer-Villiger Reactions: Uncovering the Source of Regioselectivity at Each Evolutionary Stage of a Mutant with Scrutiny of Fleeting Chiral Intermediates.
• Chain: B
• Resolution: 2.72 Å

Enzymatic activity

• Enzyme Commision number: 1.14.13.22: cyclohexanone monooxygenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	B	I14 G15 G17 G19 E39 K40 G46 T47 W48 W50 S58 D59 T60 Y65 V112 L143 N388 N436 T437	I9 G10 G12 G14 E34 K35 G41 T42 W43 W45 S53 D54 T55 Y60 V107 L138 N383 N431 T432
BS02	NAP	B	P152 I184 G185 T186 G187 S188 T189 R209 T210 R329 A379 T380 G381 W492	P147 I179 G180 T181 G182 S183 T184 R204 T205 R324 A374 T375 G376 W487

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0016491 oxidoreductase activity
• GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
• GO:0018667 cyclohexanone monooxygenase activity

External links

• PDB: RCSB:7v8o, PDBe:7v8o, PDBj:7v8o
• PDBsum: 7v8o
• UniProt: A0A1L1QK40