Structure of PDB 7v6g Chain B

Receptor sequence
>7v6gB (length=338) Species: 237561 (Candida albicans SC5314) [Search protein sequence]
PPAVLSKSGVIYGKDVKDLFDYAQEKGFAIPAINVTSSSTVVAALEAARD
NKAPIILQTSQGGAAYFAGKGVDNKDQAASIAGSIAAAHYIRAIAPTYGI
PVVLHTDHCAKKLLPWFDGMLKADEEFFAKTGTPLFSSHMLDLSEETDDE
NIATSAKYFERMAKMGQWLEMEIGITGGELYTSPETVFAVYESLHKISPN
FSIAAAFGNVHNVQLRPEILGDHQVYAKKQIGTDAKHPLYLVFHGGSGST
QEEFNTAIKNGVVKVNLDTDCQYAYLTGIRDYVTNKIEYLKAPVGNPEGA
DKPNKKYFDPRVWVREGEKTMSKRIAEALDIFHTKGQL
3D structure
PDB7v6g Structure-Guided Discovery of the Novel Covalent Allosteric Site and Covalent Inhibitors of Fructose-1,6-Bisphosphate Aldolase to Overcome the Azole Resistance of Candidiasis.
ChainB
Resolution2.343 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.1.2.13: fructose-bisphosphate aldolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B H109 E173 H225 H264 H108 E172 H211 H244
BS02 6Y3 B L287 C291 R344 A348 I351 F352 L267 C271 R324 A328 I331 F332
Gene Ontology
Molecular Function
GO:0004332 fructose-bisphosphate aldolase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016829 lyase activity
GO:0016832 aldehyde-lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006094 gluconeogenesis
GO:0006096 glycolytic process
GO:0051701 biological process involved in interaction with host
GO:0052553 symbiont-mediated perturbation of host immune response
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009277 fungal-type cell wall
GO:0009986 cell surface
GO:0030446 hyphal cell wall

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7v6g, PDBe:7v6g, PDBj:7v6g
PDBsum7v6g
PubMed
UniProtQ9URB4|ALF_CANAL Fructose-bisphosphate aldolase (Gene Name=FBA1)

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