Structure of PDB 7v0b Chain B

Receptor sequence
>7v0bB (length=528) Species: 1894 (Kitasatospora aureofaciens) [Search protein sequence]
RPYDVVIIGSGLSGTMLGSILAKHGFRIMLLDGAHHPRFAVGESTIGQTL
VVLRLISDRYGVPEIANLASFQDVLANVSSSHGQKSNFGFMFHRDGEEPD
PNETSQFRIPSIVGNAAHFFRQDTDSYMFHAAVRYGCDARQYYRVENIEF
DDGGVTVSGADGSTVRARYLVDASGFRSPLARQLGLREEPSRLKHHARSI
FTHMVGVDAIDDHVDTPAELRPPVPWNDGTMHHIFERGWMWIIPFNNHPG
ATNPLCSVGIQLDERRYPARPDLTPEEEFWSHVDRFPAVQRQLKGARSVR
EWVRTDRMQYSSSRTVGERWCLMSHAAGFIDPLFSRGLSNTCEIINALSW
RLMAALREDDFAVERFAYVEELEQGLLDWNDKLVNNSFISFSHYPLWNSV
FRIWASASVIGGKRILNALTRTKETGDDSHCQALDDNPYPGLWCPLDFYK
EAFDELTELCEAVDAGHTTAEEAARVLEQRVRESDWMLPALGFNDPDTHH
INPTADKMIRIAEWATGHHRPEIRELLA
3D structure
PDB7v0b Crystal structures and complex formation of halogenase CtcP and FAD reductase CtcQ from the chlortetracycline biosynthetic pathway
ChainB
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.19.49: tetracycline 7-halogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD B G24 S26 D45 G46 R51 V54 G55 R134 S187 R190 M321 H338 F342 P345 S348 G350 L351 G11 S13 D32 G33 R38 V41 G42 R121 S174 R177 M308 H325 F329 P332 S335 G337 L338
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0071949 FAD binding
Biological Process
GO:0017000 antibiotic biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7v0b, PDBe:7v0b, PDBj:7v0b
PDBsum7v0b
PubMed
UniProtA0A1E7MYN1|CTCP_KITAU Tetracycline 7-halogenase (Gene Name=ctcP)

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