Structure of PDB 7uu5 Chain B

Receptor sequence
>7uu5B (length=379) Species: 9544 (Macaca mulatta) [Search protein sequence]
MKPQIRNMVEPMDPRTFVSNFNNRPILSGLDTVWLCCEVKTKDPSGPPLD
AKIFQGKVYPKAKYHPEMRFLRWFHKWRQLHHDQEYKVTWYVSWSPCTRC
ANSVATFLAKDPKVTLTIFVARLYYFWDPDYQQALRILAEAGATMKIMNY
NEFQDCWNKFVDGRGKPFKPWNNLPKHYTLLQATLGELLRHLMDPGTFTS
NFNNKPWVSGQHETYLCYKVERLHNDTWVPLNQHRGFLRNQAPNIHGFPK
GRHAALCFLDLIPFWKLDGQQYRVTCFTSWSPCFSCAQEMAKFISNNEHV
SLCIFAARIYDDQGRYQEGLRTLHRDGAKIAMMNYSEFEYCWDTFVDRQG
RPFQPWDGLDEHSQALSGRLRAILQNQGN
3D structure
PDB7uu5 Structural basis of sequence-specific RNA recognition by the antiviral factor APOBEC3G.
ChainB
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.4.-
3.5.4.38: single-stranded DNA cytosine deaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna B R24 I26 L27 S28 Y59 W94 Y124 Y125 W127 K270 R24 I26 L27 S28 Y59 W94 Y124 Y125 W127 K266
BS02 ZN B H65 E67 C100 H65 E67 C100
BS03 ZN B H257 C287 C290 H253 C283 C286
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004126 cytidine deaminase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0009972 cytidine deamination
GO:0010526 retrotransposon silencing
GO:0045087 innate immune response
GO:0051607 defense response to virus
GO:0070383 DNA cytosine deamination
Cellular Component
GO:0000932 P-body
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7uu5, PDBe:7uu5, PDBj:7uu5
PDBsum7uu5
PubMed36470880
UniProtM1GSK9

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