Structure of PDB 7uu3 Chain B

Receptor sequence
>7uu3B (length=370) Species: 9544 (Macaca mulatta) [Search protein sequence]
NMVEPMDPRTFVSNFNNRPILSGLDTVWLCCEVKTKDPSGPPLDAKIFQG
KVYPKAKYHPEMRFLRWFHKWRQLHHDQEYKVTWYVSWSPCTRCANSVAT
FLAKDPKVTLTIFVARLYYFWKPDYQQALRILAEAGATMKIMNYNEFQDC
WNKFVDGRGKPFKPWNNLPKHYTLLQATLGELLRHLMDPGTFTSNFNNKP
WVSGQHETYLCYKVERLHNDTWVPLNQHRGFLRNQAPNIHGFPKGRHAAL
CFLDLIPFWKLDGQQYRVTCFTSWSPCFSCAQEMAKFISNNEHVSLCIFA
ARIYDDQGRYQEGLRTLHRDGAKIAMMNYSEFEYCWDTFVDRQGRPFQPW
DGLDEHSQALSGRLRAILQN
3D structure
PDB7uu3 Structural basis of sequence-specific RNA recognition by the antiviral factor APOBEC3G.
ChainB
Resolution3.099 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.5.4.-
3.5.4.38: single-stranded DNA cytosine deaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna B R24 I26 L27 S28 Y59 W94 Y124 Y125 W127 N176 K270 R18 I20 L21 S22 Y53 W88 Y118 Y119 W121 N166 K260
BS02 ZN B H65 C97 C100 H59 C91 C94
BS03 ZN B H257 C287 C290 H247 C277 C280
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004126 cytidine deaminase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0009972 cytidine deamination
GO:0010526 retrotransposon silencing
GO:0045087 innate immune response
GO:0051607 defense response to virus
GO:0070383 DNA cytosine deamination
Cellular Component
GO:0000932 P-body
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7uu3, PDBe:7uu3, PDBj:7uu3
PDBsum7uu3
PubMed36470880
UniProtM1GSK9

[Back to BioLiP]