Structure of PDB 7usy Chain B

Receptor sequence
>7usyB (length=602) Species: 6239 (Caenorhabditis elegans) [Search protein sequence]
TRQALLERIRQKKEVIGKLRCQAWSMTRKRRTLKLAQKYLEQHESKVSRS
HLYMEEMRKRARLMKRSFSNFKTYLIPWESKIKRIESHFGSVVSSYFTFL
RWIVFVNIMITLIALVFVVLPETLADSVANEGRFNRTKTRKQIPANERVH
ADELAVVWHYDGYLRYSPLFYGYYSDDPFLGNKIKYALPLAYFMVTLTIF
AYSFFAILRKMAANARMSKLSGSKAEQYIFNWKLFTGWDYTIGNSETASN
TVMAVVIKLRESIADIKKDAHGKFRLLQFSLRVFANIIICAMLGFSIYCI
IFAVQKSQVQDDGNLFTKNQVPSVVSTITHVFPMIFDLIGKMENYHPRTA
LRAHLGRVLILYTVNYITLIFALFEKMTALRDRVNNDICWETIIGQEIVK
LVTMDLIFTILSILVIDLFRGLWIKYCSSWWCWDIETTFPEYGEFKVAEN
VLHIINNQGMIWLGLFFAPLLPAINNIKLIILMYIRGWAVMTCNVPAREI
FRASRSSNFYLGILLIWLLLCTLPVGFVIASMSPSRSCGPFARYQHFYTV
VTREIEKRVDQTVLSYIRHIASPGVVIPIILFLILIIYFLFSLVRGLREA
NT
3D structure
PDB7usy Structures of the TMC-1 complex illuminate mechanosensory transduction.
ChainB
Resolution3.54 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA B D695 N772 D417 N494
BS02 CA B D683 N734 D405 N456
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005272 sodium channel activity
GO:0008381 mechanosensitive monoatomic ion channel activity
Biological Process
GO:0007606 sensory perception of chemical stimulus
GO:0034220 monoatomic ion transmembrane transport
GO:0035725 sodium ion transmembrane transport
GO:0050906 detection of stimulus involved in sensory perception
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0043025 neuronal cell body
GO:0097730 non-motile cilium

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Cellular Component
External links
PDB RCSB:7usy, PDBe:7usy, PDBj:7usy
PDBsum7usy
PubMed36224384
UniProtD3KZG3|TMC1_CAEEL Transmembrane channel-like protein 1 (Gene Name=tmc-1)

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