Structure of PDB 7us2 Chain B

Receptor sequence
>7us2B (length=347) Species: 9606 (Homo sapiens) [Search protein sequence]
SEAKYQEKQRKREAEERRRFPLEQRLKEHIIGQESAIATVGAAIRRKENG
WYDEEHPLVFLFLGSSGIGKTELAKQTAKYMHKDAKKGFIRLDMSEFQER
HEVAKFIGSPPGYVGHEEGGQLTKKLKQCPNAVVLFDQVDKAHPDVLTIM
LQLFDEGRLTDGKGKTIDCKDAIFIMTSNVASDEIAQHALQLRQEALEMS
RNRIAETISKNFKENVIRPILKAHFRRDEFLGRINEIVYFLPFCHSELIQ
LVNKELNFWAKRAKQRHNITLLWDREVADVLVDGYNVHYGARSIKHEVER
RVVNQLAAAYEQDLLPGGCTLRITVEPKLRLEIIDKDSKTRRLDIRA
3D structure
PDB7us2 PARL-cleaved Skd3 (human ClpB) E455Q Nucleotide Binding Domain hexamer bound to ATPgammaS, open conformation
ChainB
Resolution2.76 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B G429 Y430 V431 G112 Y113 V114
BS02 AGS B H346 I348 G384 I385 G386 K387 T388 E389 Q455 N496 F571 L579 R620 K623 H29 I31 G67 I68 G69 K70 T71 E72 Q138 N179 F243 L251 R292 K295
BS03 MG B T388 D454 T71 D137
BS04 AGS B H373 R561 H56 R233
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:7us2, PDBe:7us2, PDBj:7us2
PDBsum7us2
PubMed37163603
UniProtQ9H078|CLPB_HUMAN Mitochondrial disaggregase (Gene Name=CLPB)

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