Structure of PDB 7uqi Chain B

Receptor sequence
>7uqiB (length=579) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
VDMNVNFDDIGGLDNYIDQLKEMVALPLLYPELYQNFNITPPRGVLFHGP
PGTGKTLMARALAASCSSDERKITFFMRKGADILSKWVGEAERQLRLLFE
EAKKHQPSIIFFDEIDGLAPVRSSKQEQIHASIVSTLLALMDGMDNRGQV
IVIGATNRPDAVDPALRRPGRFDREFYFPLPDVKARFKILQIQTRKWSSP
LSTNFIDKLAFLTKGYGGADLRSLCTEAALISIQRSFPQIYRSNDKLLVD
PSKIKVKVSDFMLALKKIVPSSARSTGSSPQPLPELIKPLLADQLNNLKN
KLDYMLNIKDTTFQRNTSLLQNFIDYEEYSSFRSYEFFESMAESQICKPR
LLINGPKGNGQQYVGAAILNYLEEFNVQNLDLASLVSESSRTIEAAVVQS
FMEAKKRQPSVVFIPNLDIWINTIPENVILVLSGLFRSLQSNEKILLLCL
AENLDISEVKNGILSDFAFDKNIFQLHKPSKENITRYFSNLIELLKTKPS
DIPMKKRRVKPLPELQKVKELILTPEQIKKVSACLIEHCQNFTVSQLEDV
HSSVAKIIWKSKSAWDKTGTVDEIIKFLS
3D structure
PDB7uqi The Saccharomyces cerevisiae Yta7 ATPase hexamer contains a unique bromodomain tier that functions in nucleosome disassembly.
ChainB
Resolution3.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP B I415 G416 G457 T458 G459 K460 T461 L462 I594 G623 A624 I10 G11 G52 T53 G54 K55 T56 L57 I189 G218 A219
BS02 ADP B D547 R573 D142 R168
Gene Ontology
Molecular Function
GO:0003682 chromatin binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0042393 histone binding
GO:0140658 ATP-dependent chromatin remodeler activity
GO:0140674 ATP-dependent histone chaperone activity
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0006261 DNA-templated DNA replication
GO:0006325 chromatin organization
GO:0006334 nucleosome assembly
GO:0006337 nucleosome disassembly
GO:0006338 chromatin remodeling
GO:0034080 CENP-A containing chromatin assembly
GO:0045815 transcription initiation-coupled chromatin remodeling
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:2000219 positive regulation of invasive growth in response to glucose limitation
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7uqi, PDBe:7uqi, PDBj:7uqi
PDBsum7uqi
PubMed36592926
UniProtP40340|ATAD2_YEAST ATPase histone chaperone YTA7 (Gene Name=YTA7)

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