Structure of PDB 7up1 Chain B

Receptor sequence
>7up1B (length=241) Species: 573 (Klebsiella pneumoniae) [Search protein sequence]
EIRPTIGQQMETGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLI
VRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGM
DALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGP
LKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHY
AASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR
3D structure
PDB7up1 Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates.
ChainB
Resolution1.11 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B H120 H122 H189 H91 H93 H160
BS02 ZN B D124 C208 H250 D95 C179 H221
BS03 NZR B I35 W93 H122 D124 H189 C208 K211 N220 H250 I6 W64 H93 D95 H160 C179 K182 N191 H221
Gene Ontology
Molecular Function
GO:0008800 beta-lactamase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0017001 antibiotic catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7up1, PDBe:7up1, PDBj:7up1
PDBsum7up1
PubMed36475645
UniProtE9NWK5

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