Structure of PDB 7umy Chain B

Receptor sequence
>7umyB (length=254) Species: 575584 (Acinetobacter baumannii ATCC 19606 = CIP 70.34 = JCM 6841) [Search protein sequence]
GLLAGKRFLIAGVASKLSIAYGIAQALHREGAELAFTYPNEKLKKRVDEF
AEQFGSKLVFPCDVAVDAEIDNAFAELAKHWDGVDHSIGFAPAHTLDGDF
TDVTDRDGFKIAHDISAYSFVAMARAAKPLLQARQGCLLTLTYQGSERVM
PNYNVMGMAKASLEAGVRYLASSLGGIRVNAISAGPIRTLAASGIKSFRK
MLDANEKVAPLKRNVTIEEVGNAALFLCSPWASGITGEILYVDAGFNTVG
MSQS
3D structure
PDB7umy An Iterative Approach Guides Discovery of the FabI Inhibitor Fabimycin, a Late-Stage Antibiotic Candidate with In Vivo Efficacy against Drug-Resistant Gram-Negative Infections
ChainB
Resolution2.74 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 1.3.1.9: enoyl-[acyl-carrier-protein] reductase (NADH).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NUC B F96 A97 L102 N158 Y159 A199 I203 F206 F90 A91 L96 N152 Y153 A191 I195 F198
BS02 NAD B G15 A17 S21 I22 P42 D66 V67 S93 I94 G95 I121 L147 T148 Y149 K166 A192 P194 I195 T197 G12 A14 S18 I19 P39 D63 V64 S87 I88 G89 I115 L141 T142 Y143 K160 A184 P186 I187 T189
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004318 enoyl-[acyl-carrier-protein] reductase (NADH) activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0006633 fatty acid biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7umy, PDBe:7umy, PDBj:7umy
PDBsum7umy
PubMed36188352
UniProtD0CAD5

[Back to BioLiP]